We generated a stable H295R cell line expressing aldosterone synthase gene (CYP11B2) promoter/luciferase chimeric reporter construct that is highly sensitive to angiotensin II (AII) and potassium, and defined AII receptor blocker (ARB) effects. In the presence of AII, all ARBs suppressed AII-...
angiotensin II type 1 receptor blockers was associated with enhanced beta cell function.ConclusionThe modifiable factors of abdominal obesity, antihypertensive ... PH Dessein,BI Joffe - 《Arthritis & Rheumatism》 被引量: 140发表: 2014年 Direct regulation of insulin secretion by angiotensin II in h...
Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers. ObjectiveTo explore the involvement of the renin鈥揳ngiotensin system (RAS) in the development of vascular damage in adjuvant-induced arthritis (AIA...
产品活性:Angiotensin II human (Angiotensin II) TFA 是一种血管收缩剂,是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human TFA 在调节人类血压中起着核心作用,主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来...
Long-acting drugs that extend their action to cover this vulnerable period are preferable, especially those that block the renin–angiotensin–aldosterone system, such as ACE inhibitors and angiotensin receptor blockers, and are the most effective in controlling blood pressure and preventing or reducing...
[210,211,212,213]. In general, meta-analyses have shown that ACE-inhibitors, angiotensin receptor blockers (ARBs) and calcium channel blockers are more effective than beta-blockers at regressing LVH [214,215]. Multiple studies have shown that “CHIP” diuretics (chlorthalidone, indapamide and...
[210,211,212,213]. In general, meta-analyses have shown that ACE-inhibitors, angiotensin receptor blockers (ARBs) and calcium channel blockers are more effective than beta-blockers at regressing LVH [214,215]. Multiple studies have shown that “CHIP” diuretics (chlorthalidone, indapamide and...
It has been well-characterized that the renin-angiotensin system (RAS) physiologically regulates systemic arterial pressure. However, RAS signaling has also been shown to increase cell proliferation during malignancy, and angiotensin receptor blockers (ARBs) are able to decrease pro-survival signaling ...
J. et al. Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers. Kidney Int. 82, 330 (2012). Article CAS PubMed Google Scholar D’Elia, L. et al. Meta-analysis of the effect of dietary sodium restriction with or without ...
pharmacological AT1R block (angiotensin receptor blockers (ARBs) or stimulation of Ang II/AT2R signaling, also appears to confer a survival benefit in an experimental model of CM [28]. Furthermore, studies on a human model of endogenous AT1R antagonism, in patients with Bartter's/Gitelman's...