In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a
This study examines the impact of artificial intelligence (AI) on loss in decision-making, laziness, and privacy concerns among university students in Pakistan and China. Like other sectors, education also adopts AI technologies to address modern-day cha
To migrate into surrounding tissues and metastasize, tumor cells undergo a broad range of physical and functional alterations, including cytoskeletal rearrangements and remodeling of the extracellular matrix (ECM).2, 3 Motile tumor cells assume several phenotypes, including a mesenchymal mode, in which ...
Extreme independent variation in the expression of pairs of HLA-associated transcripts (HLA-B/C, HLA-A/F and HLA-DRB1/DRB5) in macrophages was associated with HLA genotype. Correlation analysis indicated the downstream impacts of variation in the immediate early response to LPS. For example, ...
Human centromeres have been traditionally very difficult to sequence and assemble owing to their repetitive nature and large size1. As a result, patterns of human centromeric variation and models for their evolution and function remain incomplete, despit
With the activated THP-1 cells, several of the flavoring chemicals that are components of various essential oils had a suppressive effect on inflammation and inflammatory cytokine secretion, which is consistent with published assessments [38,39,40]. The assortment of patterns seen in the toxicity ...
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene: the gene product responsible for transporting chloride and bicarbonate ions through the apical membrane of most epithelial cells. Major clinical features of CF include ...
Originating in the area of multimedia information system design [2–6], experiential computing supports data analysis by combining user expertise with information visualization and algorithms in a tight loop. We also study two biological data analysis systems based on this design paradigm. The first ...
Such pioneering approach based on combining the OMICs tools with established oocyte quality parameters mainly the ZP birefringence should lead to an integrative strategy that will accurately predict the oocyte developmental potential. A clinical tool that use both molecular biomarkers and ZP birefringence ...
Here, we characterize oro-dental manifestations and physical features of patients with novel KMT2D and KDM6A mutations. The mutations were identified by Whole Exome Sequencing (WES) and confirmed by Sanger sequencing. In addition, the expression of KMT2D and KDM6A during tooth development was demo...