The 12th Human Amyloid Imaging (HAI) Conference was held in January in Miami Beach, Florida, to discuss topics such as the presence of brain amyloid, how it should be measured and how it changes. This report highlights a selection of presentations from the meeting.Cole, P.Bofill, X....
et al. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system. Biochem. Biophys. Res. Commun. 314, 363–369 (2004). Article CAS ...
Amyloid beta (Aβ) has been strongly implicated in driving tau spread, whereas primary tauopathies such as primary age-related tauopathy (PART)—which lack Aβ pathology—exhibit limited tau spread and minimal-to-no cognitive decline. Emerging evidence converges on a trans-synaptic mechanism of ...
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et al. White matter integrity determined with diffusion tensor imaging in older adults without dementia: Influence of amyloid load and neurodegeneration. JAMA Neurol. 71, 1547–1554 (2014). Article PubMed PubMed Central Google Scholar Rabin, J. S. et al. Global white matter diffusion ...
amyloid beta and myelin. Significantly, the toolkit facilitates repeated iMG harvesting, essential for large-scale experiments like CRISPR-Cas9 screens. The standalone ATAC-Seq profiles of our iMG closely resemble primary microglia, positioning them as ideal tools to study AD-associated single nucleotide...
backed Leqembi to treat mild cognitive impairment or mild dementia from Alzheimer’s but only for patients carrying one or no copy of the ApoE4 gene. Patients with two copies of the gene are at greater risk of brain swelling or bleeding side effects known as amyloid-related imaging a ...
Amyloid‐related imaging abnormalities (ARIA) on MRI are frequently observed adverse advents in the context of anti〢β immunotherapy trials in patients with Alzheimer's disease (AD). The underlying histopathology and mechanisms of ARIA remain unknown, although coexisting Cerebral Amyloid Angiopathy (...
Amyloid-imaging agents could also serve as surrogate markers in early diagnosis and neuropathogenesis studies of Alzheimer's disease and other aging-related neurodegenerative disorders. In this review article, the design and biological evaluation of amyloid-imaging agents are discussed. The structures of...
Alzheimer’s disease (AD) is the most common age-related form of dementia, associated with deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated microtubule-associated protein tau (p-tau) and extracellular plaques primarily comprising amyloid- β (Aβ) peptide. The p...