结果:(1)腹腔注射h UCMSC-EVs可显著提高ITP小鼠外周血的血小板数目.(2)ITP小鼠脾脏中M1巨噬细胞比例增多,经EVs治疗的小鼠M1比例下降,TNF-α,IL-6表达下降.(3)ITP小鼠脾脏中p STAT1及STAT1蛋白水平升高,EVs治疗可以下调STAT1,p STAT1的蛋白水平.结论:本研究证明h UCMSC-EVs可以提升ITP模型小鼠的血小板数目,可能...
更重要的是,温敏水凝胶在生物降解过程中缓慢释放负载的 hUCMSC-EVs,有效延长了 EVs 在子宫内膜基质细胞和小鼠宫腔中的留存时间,提高 EVs 的生物利用度。 这项研究将新型的生物材料与 EVs 疗法相结合,用于解决临床治疗 IUA 的局限,拓展了温敏水凝胶和 EVs 在 IUA 中的应用。
Both GCs and oocytes could uptake HucMSC-EVs. Moreover, we observed elevated cellular transcription in GCs and oocytes after treatment with HucMSC-EVs. The RNA sequencing (RNA-seq) results further validated that the differentially expressed genes are related to the promotion of GC proliferation, ...
This study elucidates the molecular mechanism by which hUCMSC-derived EVs regulate IVDD and could help develop novel therapeutic strategies for treating this condition. Our findings demonstrate that hUCMSCs-EVs inhibit ferroptosis in nucleus pulposus cells, thereby improving IVDD. These results highlight...