Cantuzumab ravtansine (IMGN242; huC242-DM4) 是一种抗体-药物偶联物(ADC),专门靶向 CanAg(癌相关糖抗原,CanAg, CA242),在 CanAg 阳性肿瘤(如胃癌、胰腺癌等)中具有潜在的抗肿瘤活性。 由以下部分组成: 1.抗体部分:huC242,一种人源化单克隆抗体,靶向 CanAg(一种肿瘤相关抗原)。 2. 连接子:通过二硫键...
“A Phase I study of huC242-DM4 to assess the safety and pharmacokinetics of huC242-DM4 administered as a single intravenous infusion once every three weeks to subjects with solid tumors.” EORTC-NCI-AACR-2005, Molecular targets and cancer therapeutics, Philadelphia, PA 212 : Abstract #212....
514 POSTER A novel dosing strategy based on plasma levels of CanAg in a Phase II study of IMGN242 (HUC242-DM4) in gastric cancerTolcherA.WatermillJ.MasticoR. A.LutzR. J.OKeeffeZildjianEUROPEAN JOURNAL OF CANCER -SUPPLEMENT-
514 POSTER A novel dosing strategy based on plasma levels of CanAg in a Phase II study of IMGN242 (HUC242-DM4) in gastric cancerPublication » 514 POSTER A novel dosing strategy based on plasma levels of CanAg in a Phase II study of IMGN242 (HUC242DM4) in gastric cancer....