SCID小鼠免疫重建人肺癌转移将人外周血淋巴细胞经腹腔移植于T,B细胞严重联合免疫缺陷的SCID小鼠后,成功地建立了hu- PBL-SCID小鼠模型.在移植后4周,其小鼠血清中存在人免疫球蛋白,其脾淋巴细胞中,所检测的8种免疫表型人淋巴细胞亚群均存在,表明人淋巴细胞在 SCID小鼠体内出现了增殖或重建.但hu-PBL-SCID小鼠及未免疫...
第二部分hu-PBL.SCID鼠膀胱癌模型的建立及其生物学特性观察 目的:建立人外周血淋巴细胞免疫重建的SCID鼠膀胱癌淋巴道转移模型,观察体外 筛选获得的人膀胱癌细胞株高侵袭性亚群T24.III细胞与其母代细胞T24的体内侵袭与转移 山蘸辩大学硕士学位论立 情况,并评价该模型用于DCs疫苗干预膀胱癌淋巴结微转移的可行性。
1. hu-PBL-SCID小鼠体内人淋巴细胞状况及其对人肺癌移植瘤转移的影响 2. 脾细胞移植诱导大鼠小肠移植微嵌合体形成的实验研究 3. 利用敲除PLCξ基因的JM8细胞制备嵌合体小鼠 4. 小鼠混合骨髓移植中脾细胞诱导持久稳定嵌合体的作用 5. 免疫重建SCID小鼠B淋巴母细胞瘤模型的建立 6. 植物遗传嵌合体及其在观赏...
目的 通过重建人肝癌PBL-SCID嵌合模型来观察mRNA致敏的树突状细胞疫苗(mRNA DC)在体内的抑瘤效应并探讨机制.方法 采用人外周血淋巴细胞腹腔注射法建立Hu-PBL-SCID鼠模... 谢斌辉,刘凤恩,王小农,... - 《岭南现代临床外科》 被引量: 3发表: 2008年
Hu-PBL-SCID Mouse We established seven new mouse strains with defective T and B cells as well as innate immunological reactions, and showed that six mutant mouse strains efficiently received human PBL engraftment (hu-PBL-mouse) . Increased levels of macro... Y Koyanagi,Y Tanaka,M Ito,... ...
In vivo inhibition of anti-HBCIGG production by HBCAG-specific CD4+ TH1-type T cell clones in a HU-PBL-NOD/SCID mice model: Tinghua Cao, Philip Meuleman, Isabelle Desombere, Ghent University, Ghent Belgium; Matti Sällberg, Karolinska Institute at Huddinge University Hospital, Huddinge ...
Transplantation of hu-PBL into SCID mice without prior conditioning of the mice resulted in detectable differences in quantitative histological scores of brain inflammation due to Toxoplasma gondii infection, but did not alter mortality when compared to SCID mouse controls. The lack of detectable ...
Evaluation of gp160 vaccinees in the hu-PBL-SCID mouse model. A comparison of the proliferative responses of lymphocytes to human immunodeficiency virus (HIV) antigens from long-term, seronegative heterosexual partner... DE Mosier,RJ Gulizia,P Macisaac,... - 《Aids Research & Human Retroviruses...
Mosier DE,Picchio GR,Kirven MB,et al.EBV-inducedhuman B cell lymphomas in hu-PBL-SCID mice. AIDSRes Hum Retroviruses . 1992Mosier DE; Picchio GR; Kirven MB;.EBV-induced human B cell lymphomas in hu-PBL-SCID mice.AIDS Res Hum Retrovimses.1992.735-740...
hu-PBL-SCID鼠为了探讨人白细胞介素 18(hIL 18)的表达对鼻咽癌细胞体内致瘤性的影响 ,我们构建了hIL 18的真核表达载体pcD NA3/hIL 18,转染人鼻咽癌细胞株SUNE细胞 ;然后以转染阳性的SUNE细胞和未转染的SUNE细胞接种到用健康人外周血白细胞免疫重建的SCID鼠 (hu PBL SCID鼠 ) ,观察成瘤情况.结果发现 ,所...