EXECUTIVE functionThe Huntingtin gene (HTT) is within a class of genes containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. Individuals with less than 35 repeats are not associated with HD. Increasing evidence has ...
Huntingtin is a gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. However, the mechanisms by which mutant huntingtin leads to neurodegeneration in Huntington's disease (HD) are still not fully understood. Studying the normal functions of huntin...
The serotonin transporter (5-HTT) plays a critical role in regulation of serotonergic function. A recently identified polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) produces significant differences in 5-HTT expression and function and was found to be associated with anxiety-...
Relationship between 5-HTT gene polymorphism and clinical response in the treatment of depressive patients with SSRIs and SNRIs Objective To investigate the relationship between serotonin transporter (5-HTT) gene polymorphism and clinical response of selective serotonin reuptacke in... H Xiao,H Yao...
A functional polymorphism in the promoter region of the serotonin transporter (5-HTT) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HTT promoter polymorphism exhibited more depressive symptoms, ...
extractRepeatsAllSamples <- function(targetList=c("HTT","FMR1","ALS","SCA10"), rerun=FALSE){ require(seqinr) analyzeRepeatsInSample(fastaFile="CCS_reads/genscript_rep1_CCS.fasta", sampleName="genscript_rep1", outdir="analysis_results", targetList=targetList, rerun=rerun) analyzeRepeatsIn...
Differential expression was performed using the DESeq-function with default settings and results were extracted with disabled independent filtering. Genes with an adjusted P-value (Benjamini-Hochberg) of <0.1 were considered significantly differentially expressed. Official gene symbols were assigned to ...
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT GeneSerotonin transporterMajor depressionMood disordersEvents... A Caspi,K Sugden,Moffitt TE.,... - 《Science》 被引量: 1.4万发表: 2003年 Modulation of serotonin transporter function by interleukin-4 influence of ...
参见例如Chevalier等(2002)Molec.Cell 10:895-905;Epinat等(2003)Nucleic Acids Res.31:2952-2962;Ashworth等(2006)Nature441:656-659;Paques等(2007)Current Gene Therapy 7:49-66;美国专利公开号2007/0117128。 [0096] “双手(Two handed)”锌指蛋白是这样的蛋白质,其中两簇锌指DNA结合结构域通 过介于中间...
May play a role in microtubule-mediated transport or vesicle function.;Promotes the formation of autophagic vesicles. Swiss Prot P42858 Gene ID 3064 亚细胞定位 Cytoplasm Nucleus 免疫原 A synthetic peptide of human HTT Public Immunogen Range 2900-2950/3142aa 理论分子量 348kDa 其它标识 纯化方法 Affi...