All protocols and experimental plans were approved by the Brigham and Women’s Hospital Institutional Animal Care and Use Committee (Protocol #2016N000416). Isolation and purification of nuclei from enteric neurons The isolation of enteric neurons from Tg(Uchl1-HISTH2BE/mCherry/EGFP*) Fsout/J ...
Serotonergic neurons in the central nervous system control behavior and mood, but knowledge of the roles of serotonergic circuits in the regulation of immune homeostasis is limited. Here, we employ mouse genetics to investigate the functions of enteric serotonergic neurons in the control of immune res...
Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome a
Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. FASEB J 2011; 25: 737–753. 51. Louboutin JP, Fichter-Gagnepain V, Pastoret C, Thaon E, Noireaud J, Sebille A et al. ...