In addition, in situ hybridization26,27 and immunohistochemical studies using antibodies specific to 5-HT3R28,29,30,31,32,33 have been performed in various rodent species. These findings have shown that the highest level of expression of 5-HT3R can be observed in the spinal cord (especially...
Consistent with the reduced TPH2 expression and 5-HTP accumulation in the midbrain of Gria15-HT À / À mice, tissue levels of 5-HT were reduced by 41% relative to controls (p ¼ 0.006), while levels of the 5-HT metabolite 5-HIAA were decreased by 33% (p ¼ 0.029) (Table...
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Evaluating the role of Ht31 on synaptic plasticity.MyungSook, KimAlan, Jung ParkRobbert, HavekesAndrew, ChayLeonardo, Antonio GuercioRodrigo, Freire OliveiraTed, AbelKim, T. Blackwell
© Springer International Publishing AG, Part of Springer Science+Business Media Privacy Policy, Disclaimer, General Terms & Conditions 沪ICP备13017623号 Not logged in Unaffiliated 202.46.50.183 Springer for Research & Development The ability of 5-HT3receptor antagonists such as ondansetron, tropiset...
Murnane KS, Winschel J, Schmidt KT, Stewart LM, Rose SJ, Cheng K et al (2013). Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates. J Neurosci 33: 13367–13374. Article CAS ...
Bax is an apoptotic protein [33]. Bax and Bcl-2 can interact and form a complex regulatory network in the regulation of apoptosis. Therefore, with a low level of Bax, induction of apoptosis may require upregulation of Bax expression. In addition, apoptosis is a well-controlled process ...
Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, Regan CM, Upton N: SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in...
Taken together, our data sug- gsieosnteidntahamt asnevneerradl sifufebrteynptefsroofmprtehsoysneagpotivce5rn-HinTg2trheecpepotsotsrydniaffpetriecnetfifaelclyt.modulated inhibitory synaptic transmis- Discussion OsyunrapptriecsetrnatnsstmudisysdioenmsoinnshturamteadnpirPeSs-ydnearpivtiecdannedupro...