Of note, pre-existing HSV-1 IgG had no impact on T3011 activity. Conclusions: IV T3011 monotherapy was well tolerated and safe at the first 3 dose levels, highly unlikely to be transmissible. Preliminary efficacy was encouraging. Our results also suggest T3011 IV treatment could stimulate ...
Immunoglobulin (IgG) tests: Used to detect a longer-lasting antibody, which can help differentiate between a recent infection and a recurrence Certain IgG blood tests can also tell you whether you have HSV-1 or HSV-2. CDC Screening Recommendations The CDC does not recommend herpes testing for ...
Oncolytic viruses (OVs) show promise as a cancer treatment by selectively replicating in tumor cells and promoting antitumor immunity. However, the current immunogenicity induced by OVs for tumor treatment is relatively weak, necessitating a thorough inv
Our herpes simplex virus type 1 and 2 (IgG) type-specific antibody testing screens the blood for antibodies to both types of the herpes virus by using an immunoassay. If enough antibodies are detected, then the tester is positive for the corresponding virus. Even without signs of an outbreak...
(LYVE-1+). Horizontal bars depict mean percentage threshold of thez-stacked area positive for blood and lymphatic vessels ± SEM. *p < 0.05 comparing the indicated groups as determined by unpaired, two-tailed t-test comparison, n = 5 per treatment, two repetitions. Discontinuous...
The percentage of SGN survival from each treatment group was calculated as the number of NF 200-positive neurons in treated cultures divided by the number of NF 200-positive neurons detected in untreated control explant cultures multiplied by a factor of 100 (n = 3). Discussion The results of...
However, the UD-SCC-2 also presented induction of late apoptosis by the presence of rhTRAIL in monotherapy. These data suggest an enhancement of the effect of the combination treatment of the rhTRAIL and the HSV-1 on reducing viability and induction of cell death....
(1:1,000; Invitrogen MA12022), HSV-tk (1:400; Invitrogen PA5-67984), Alexa Fluor 488-conjugated goat anti-mouse IgG (1:1,000; Invitrogen A28175), Alexa Fluor 555-conjugated goat anti-mouse IgG (1:1,000; Invitrogen A21422), and Alexa Fluor 647-conjugated goat anti-rabbit IgG (1:...
Cytometric evaluation of transduction efficiency was performed by staining with 20.4 mouse anti–human ΔLNGFR monoclonal antibody (mAb) followed by FITC-conjugated goat anti–mouse IgG1. To calculate transduction efficiency, the negative control (cells stained with FITC-conjugated goat anti–mouse IgG1...
ELISA-IgM-HSV-1/2 was not positive in any case or control. ELISA-IgG-HSV-1/2 was positive in 11 (34 %) cases and nine (30 %) controls (p = 1.0). Qualitative PCR for HSV-1 detected the virus in eight (25 %) cases and nil controls (p = 0.009). HSV-2 was not ...