在病毒攻击后,将HSV‑2IgG2特异性抗体快速招募至HSV‑2ΔgD‑2接种 的小鼠的皮肤中。(11A)用ΔgD‑2或VD60细胞裂解物(对照)对小鼠进行免疫,并且随后用 3 HSV‑1(B x1.1)和HSV‑2(SD90)临床分离株在皮肤上攻击。加强后21天和攻击后2天获得皮 肤活检,并且使用HSV‑2(左)或HSV‑1(右)感染...
The levels of VZV and HSV-2 IgG antibodies were evaluated using commercial ELISA kits. Subsequently, the results were analyzed using SPSS software. Results: A total of 93 women were included in the study. Anti-HSV-2 IgG antibody was detected in 3 out of 93 particip...
To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells. We explored the regulatory effects of berberine on the immune response
In the present study, we investigated whether HIV-1 and HSV-2 may interact at the cellular level by forming HIV-1 hybrid virions pseudotyped with HSV-2 envelope glycoproteins, as was previously reported for HSV type 1. Methods We evaluated in vitro the production of HSV-2/HIV-1 pseudo...
使用重组单纯疱疹病毒2(hsv ‑ 2)疫苗载体的免疫的被动转移 1.相关申请的引证 2.本pct国际申请要求2019年1月3日提交的美国序列号15/995,471的优先权,其是2018年6月1日提交的美国序列号15/995,471的部分继续申请,其是2016年2月4日提交的美国专利申请号15/015,322(现在是2018年6月19日授权的美国专利号9,...
HSV-2 Candidate Vaccine Virus Deleted in Glycoprotein D (螖gD-2) Elicits High-Titer IgG2 Antibodies with Antibody Dependent Cell Mediated Cytotoxicity (ADCC) Activity, Protects Mice from Skin and Vaginal Challenge with Cinical Isolates of HSV-1 and HSV-2, and Prevents the Establishment of ...
The chromatin supernatant was incubated with 5 μg antibody specific for pol II or 5 μg antibody specific for CTCF overnight at 4 °C with rotation. An aliquot was incubated with IgG (Abcam, ab2410) as a control to determine background binding. The beads were washed for ...
(A) ChIP was performed using anti-BRG1 and anti-acetyl-histone H4 Ab followed by PCR using specific primers. IgG controls showed no signal, indicating the specificity of the assays (data not shown). Lanes 1 and 2: LAT TRE ChIP primers; lanes 3-6: ICP0 promoter primers. (B) Cells ...
This raises the important possibility that the role of scavenger receptors might be specific to the route of administration, the type of receptor, and the cell target. As the subsequent recognition of viral nucleic acids by scavenger receptors is necessary for the later interferon response, it is...
Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from signifi