HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice. Virus Res. 2013;173:436-440.Wang H, Davido DJ, Morrison LA (2013) HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice. Virus Res ...
Mice were infected using corneal scarification using 5 × 105 PFU of HSV-1 McKrae strain. a–c Tissue plaque assay for trigeminal ganglion (left), brainstem (middle), and brain (right) (n = 5 mice per group). Two-tailed Mann–Whitney U test was used where p < 0.05 ind...
DNA previously purified from HSV-1 (McKrae) strain was used as a positive control and DNA previously extracted from an uninfected animal was used as a negative control. HSV-1 specific primers were used to detect HSV-1 (F strain) DNA. The primers and probe detect the HSV-1 gD gene ...
type 1 (HSV-1) ocular shedding and recurrent corneal epithelial lesions were assessed following an intravenous injection of cyclophosphamide (75 mg/kg) and 24 hr later an intravenous injection of dexamethasone (4 mg/kg) in 24 eyes of 15 rabbits latently infected with HSV-1 strain McKrae. Samp...
Compartmentalized and systemic control of tissue immunity by commensals.###HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice.###The TvLEGU-1, a legumain-like cysteine proteinase, plays a key role in Trichomonas vaginalis cytoadherence.###Vag...
As a result, the present study was undertaken to investigate the kinetics of the efficacy mediated by the IFN-α1 transgene following ocular challenge with HSV-1. METHODS. Mice were ocularly infected with a lethal dose of HSV-1 (450 plaque forming units/eye, McKrae strain) following corneal...
Adenosine-5'-monophosphate (AMP) was evaluated for efficacy in the prevention of spontaneous and induced herpes simplex virus type 1 (HSV-1) ocular shedding in latently infected rabbits with strain McKrae. Intraperitoneal injections (IP) of AMP (100 mg/kg) or NaCl (10 mg/kg) were given on...
与DLSPTK不同,DM33的突变基于McKrae毒株,具有更强的增殖能力并诱导更强烈的抗肿瘤效应。在颅内携带U-87MG人神经胶质瘤的裸鼠模型中,小鼠接受DM33治疗后其生存时间延长,组织学分析显示DM33治疗组加速了肿瘤细胞溶解。DM33的安全性在于其对神经元细胞,星形胶质细胞和内皮细胞的减毒作用。 NV1020是衍生自HSV-1的减毒...
HSV-1 strain McKrae was propagated in green monkey kidney (Vero) cells and maintained at a stock concentration of 1.7 × 108to 1.7 × 109plaque-forming units (PFU)/mL. Anesthetized mice were infected by scarification of the corneal surface with a 25-G 1½” needle and tear...
(95%), including strain 186 had the same, prevalent length forUL39. Laboratory strain HG52 clearly fell in the minorUL39branch. HSV-1 and ChHV segregated outside of these major HSV-2 groups, with ChHV closer to HSV-2 than HSV-1 from HSV-2. Aside from low prevalence SNPs and short...