(A) ChIP was performed using anti-BRG1 and anti-acetyl-histone H4 Ab followed by PCR using specific primers. IgG controls showed no signal, indicating the specificity of the assays (data not shown). Lanes 1 and 2: LAT TRE ChIP primers; lanes 3-6: ICP0 promoter primers. (B) Cells ...
在另一实施例中,gE对IgG单体的结合降低90%。在另一实施例中,结合降低50%。在另一实施例中,降低65%。在另一实施例中,降低70%。在另一实施例中,降低75%。在另一实施例中,降低80%。在另一实施例中,降低85%。在另一实施例中,降低95%。在另一实施例中,降低96%。在另一实施例中,降低97%。在另一实施例中,降低...
业内已知,HSV-2感染会使HIV-1复制增加(屋德瑞 古(Ouedraogo A)等人,在采取抗逆转录病毒疗法的女性中阻抑性疱疹疗法对生殖器 HIV-1 RNA的影响随机受控试验(Impact of suppressive herpes therapy on genital HIV匿l RNA among women taking antiretroviral therapy: a randomized controlled trial.), 艾滋病04/A5)...
Type-specific delayed hypersensitivity and protective immunity induced by isolated herpes simplex virus glycoprotein. J ImmunoI1983;130:1413-8. 31. Wells PA, Ihley TM, Foster CS. Immunisation with a synthetic HSV-1 glycoprotein D peptide protects mice from herpes simplex keratitis (HSK). Invest ...
Herpes simplex virus type 2 (HSV-2) is a major cofactor of human immunodeficiency virus type 1 (HIV-1) sexual acquisition and transmission. In the present study, we investigated whether HIV-1 and HSV-2 may interact at the cellular level by forming HIV-1 hybrid virions pseudotyped with HSV...
1感染的免疫应答的方法,该包括将来自hsv ‑ 2免疫的妊娠女性的一定量的产物被动转移至第一受试者,该hsv ‑ 2在其基因组中具有全部hsv ‑ 2糖蛋白d编码基因的缺失,并且其中,通过在表达单纯疱疹病毒 ‑ 1(hsv ‑ 1)糖蛋白d的互补细胞中增殖所述hsv ...
所述HSV‑2在其基因 组中具有全部HSV‑2糖蛋白D编码基因的缺失,并且其中,通过在表达单纯疱疹病毒‑1(HSV‑ 1)糖蛋白D的互补细胞中增殖所述HSV‑2,所述HSV‑2在表型上与所述HSV‑1糖蛋白D互补,其 中,所述产物包含由此诱导的抗体,有效引发所述第一受试者中的抗HSV‑2和/或HSV‑1感染 的...
Our focus, however, centered on transcription factors involved in gene expression regulation, gene repression, and neuron-specific functions that could be relevant to HSV-1 pathogenesis. Of the identified proteins, High Mobility Group Protein I/Y (HMG I/Y) and Trans-Activation Response (TAR) DNA...
Due to the lack of specific antibodies to gN, we can merely speculate about the localization of gN during infection. Potentially, various subpopulations of gN and gM may co-exist, gM–gN in complex with each other, as well as gN and gM proteins that travel independently of each other, ...
4B8M exhibited anti-inflammatory actions in several in vivo mouse models, such as antigen-specific skin inflammatory reactions and responses to nonspecific irritants, colon inflammation induced by dextran sulfate and allergic pleurisy induced by ovalbumin [5]. The concept of constructing such a ...