Histological examination (H&E staining) of the heart, liver, spleen, lungs, and kidneys of the treated mice showed no abnormal cellular morphology compared to the control mice (Supplementary Fig. 11 and Supplementary Fig. 12). In addition, routine blood tests and blood biochemistry analysis ...
1.U251 cellswerethe permissive cellstoHSV-1infection. 2.HSV-1infectionWasabletoleadto apoptosis inculturedU251 cellstnvitro. 3.HSV-1wasabletoinducetheabnormal expression of neurotrophic factorsand receptors inthe13251 cells.Afterinfectedwi也HSV-1,thelevelof ...
Fast-replicating neurotropic herpesviruses exemplified by herpes simplex virus-1 (HSV-1) naturally infect the central nervous system (CNS). However, most individuals intrinsically suppress the virus during a primary infection and preclude it from signifi
The progressive shrink in the population of TK+ lymphocytes surviving in vivo confirms that genetically engineered cells transduced by the SFCMM-3 retroviral vector do not show an “abnormal” proliferative/survival potential. In the patients who presented with abrupt disappearance of TK+ cells, this...
Thus, investigating the impact of HSV-1 infection on abnormal tau phosphorylation is of great importance and may shed light on the interaction between infectious agents and neurodegeneration. While tau's role in microtubule stabilization has been a significant area of study, tau has also been ...
ABNORMAL-DEVELOPMENTHERPES INFECTIONCELL RESPONSEST-CELLSPROTECTIONIMMUNIZATIONVACCINETo examine whether local immunization in the absence of secondary lymphoid organs (SLOs) could establish effective antiviral memory responses in the female genital tract, we examined immunity in the vaginal tracts of LT ...
Although most LNPs primarily traffic to the liver, newly formed vessels within a tumor are abnormal and leaky. This leakiness has been shown to result in enhanced accumulation of LNPs.59 Additionally, nanoparticles exhibiting a cationic surface charge demonstrate superior extravasation and penetration ...
A decrease in syncytin-1 expression and abnormal localization has been found in preeclampsia, a pregnancy disorder characterized by poor trophoblast differentiation and placental dysfunction [124]. On the other hand, syncytin-1 is up-regulated in glial cells of demyelinating lesions and in brain tissu...