Importantly, OVs, as pathogenic microorganisms, have a close association with innate immune sensors such as inflammasomes, which play a critical role in eliciting antitumor immune responses15,16. The mechanisms underlying the induction of innate immune responses by herpes simplex virus-1 (HSV-1) have...
Herpes simplex virus type 1 (HSV-1) has been leading the field of oncolytic virus therapy.3 Mineta et al.4 generated a second generation oncolytic HSV-1, G207, which had deletion of the γ34.5 gene and inactivation of ICP6 with a LacZ gene insertion and could replicate only in cancer ...
This study indicated that DNA-PKcs has antiviral effects and, although the consequences of this interaction between DNA-PKcs and ICP0 are not fully resolved, other NHEJ proteins may be involved in this interaction [32]. These findings are coherent with a recent study, demonstrating that HSV-1 ...
RVx201 and RVx202 were generated as previously described, by targeted mutations throughout the coding region of infected cell protein 0 (ICP0) using HSV-2 MS as a backbone [40]. WT HSV-2 stocks were generated using Vero cells from American Type Culture Collection (ATCC) while RVx201 and ...