Principal Names:SULF1, sulfatase 1, HSULF-1, SULF-1, extracellular sulfatase Sulf-1, sulfatase FP Official Symbol:SULF1 Accession Number(s):NP_055985.2 Human GeneID(s):23213 Important Comments:Reported variants NP_055985.2; NP_001121676.1; NP_001121677.1; NP_001121678.1 represent identical protein...
hSulf-1基因血管内皮细胞细胞增殖细胞运动目的 构建携带人硫酸酯酶1基因(hSulf-1)的腺病毒载体,研究其对于人脐静脉内皮细胞ECV-304增殖,迁移能力的影响.方法 通过基因操作技术将hSulf-1基因插入到腺病毒基因组中,构建重组腺病毒Ad5-hSulf1;应用蛋白质免疫印迹法检测hSulf-1蛋白在ECV-304细胞中的表达及细胞内...
nd methods of using HSulf-1 nucleic acids, polypeptides and methods of usingHSulf-1 nucleic acids, polypeptides and methods of using
Finally, in vivo experiment using OV202 Sh1 derived xenograft show that AACOCF3 treatment effectively attenuated tumor growth and LD biogenesis. Collectively, these results show a reciprocal regulation of autophagy and lipid biogenesis by HSulf-1 in ovarian cancer. Previous reports have shown that ...
Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogenic cells with and without HSulf-1 have not bee
The HSulf-1 gene encodes an extracellular 6-O-endosulfatase and regulates the sulfation status of heparan sulfate proteoglycans (HSPG). We have demonstrated that promoter hypermethylation is correlated with the HSulf-1 silencing in gastric cancer. To investigate the functional importance of HSulf-1...
基于银屑病与恶性肿瘤都具有特征性局部缺氧和细胞增殖的特点,我们推测HSulf-1可能在银屑病发生发展中发挥一定作用,本课题旨在研究HSulf-1和HIF-1α在银屑病皮损区与正常皮肤中的表达水平以及在常氧和缺氧时人永生化角质形成细胞株 HaCaT细胞中的表达情况,并构建HSulf-1基因的过表达载体便于后续进一步体内外研究其与...
多囊肾(ADPKD)是一种遗传性的肾脏病,一般发病都在中年以后。近些年来随着基因组学的进步以及基因解码的普及,大部分多囊肾患者均可以在早期得以确诊。由于多囊肾的治疗难度比较大,很容易出现反复的特点,可能让患者尤其担心。O网页链接致病基因鉴定基因解码可以用来分析检测任可一种由基因引起的疾病,它即包括所有的肿瘤类...
蔚山现代上赛季后半段主场防守下滑不少,近10个联赛主场也就1场零封,新赛季首个正赛主场就被东京FC打入关键球,导致无法赢球。蔚山现代半大能力低下,近10场正赛只有3场半场有球,即便在韩K联也是半大率很差的球多。「尚州尚武」【优】尚州尚武比赛不缺球,近17场正赛多达15场至少2球,且无1场蛋蛋,这在韩职联...
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