紫草素通过HSP90_PKM2_HIF-1α介导脂多糖诱导的RAW264.7巨噬细胞炎症反应 星级: 8页 草苁蓉多糖对脂多糖诱导的RAW264.7巨噬细胞炎症反应的影响及其机制的开题报告.docx 星级: 2页 塞来昔布对脂多糖诱导的RAW264.7巨噬细胞炎症模型炎症因子的影响 星级: 12 页 RAW264.7巨噬细胞 星级: ...
Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1alpha Signaling. Int J Mol Sci. 2020;21:1646. Article CAS PubMed Central Google Scholar Chen F, Xie H, Bao H, Violetta L, Zheng S. Combination of HSP90 and autophagy ...
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma. Mol Cancer. 2017;16:178. Article Google Scholar Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, et al. Nitric oxide ...
结论紫草素可调节LPS刺激的RAw264.7细胞M1/M2极化,改变Ml和M2型巨噬细胞标记物水平,并通过破坏HsP90/PKM2/HIF-la信号通路问相互作用,保护RAw264.7细胞减轻LPs诱导炎症反应,从而影响炎症的进展。关键词: 紫草素;脂多糖; RAw264.7细胞;PKM2/HIF-la;Arg_l中图分类号:R363文献标志码: A文章编号: 1007—6611(2023)...
The data showed that during heat stress, Hsp90 activated the PKM2-Akt signaling pathway to exert antiapoptotic effects and induce Hsp70 expression regulated by HSF-1, stimulated autophagy-mediated survival through the HIF-1α-BNIP3/BNIP3L pathway, and finally protected the kidney from heat-...
Moreover, the nuclear translocation of PKM2, (p-) Akt, HSF-1, and HIF-1伪 was enhanced by heat stress, but only intranuclear p-Akt and HSF-1 were specifically influenced by Hsp90, contributing to regulate the cellular ability of resisting heat-stress damage. Our study provided new ...