红景天苷还具有促进 HIF-1 积累的能力,有助于防止缺氧引起的细胞损伤。 香港科技大学 2012 年的一项研究发现,红景天苷可刺激肝细胞和肾细胞中 HIF-1 的积累,研究小组声称,红景天成分具有抗缺氧功效,通常摄入红景天会产生这种功效。[21] 2017年,重庆大学研究人员发现红景天苷不仅能增加HIF-1,还能促进新生血管形成。这...
红景天苷还具有促进 HIF-1 积累的能力,有助于防止缺氧引起的细胞损伤。 香港科技大学 2012 年的一项研究发现,红景天苷可刺激肝细胞和肾细胞中 HIF-1 的积累,研究小组声称,红景天成分具有抗缺氧功效,通常摄入红景天会产生这种功效。[21] 20...
Heat shock protein 90alpha (HSP90alpha), a substrate and chaperone of DNA-PK necessary for the apoptotic response Proc. Natl. Acad. Sci. U. S. A., 109 (2012), pp. 12866-12872 CrossrefView in ScopusGoogle Scholar 5 M. Ferrarini, S. Heltai, M.R. Zocchi, C. Rugarli Unusual expres...
We selected a tumour cell model to investigate the previously raised questions, based on the fact that the best-characterized oncogene that triggers Hsp90α secretion is hypoxia-inducible factor-1 alpha (HIF-1α), which is overexpressed in more than 50% of all invasive tumours in humans35. ...
4.1.1. A12 and A16 In 2017, Ihrig and Obermann48 reported the disclosure of small molecules that disrupt interactions between Aha1 and Hsp90. Using an Alpha screening assay, they identified A12 and A16 (1 and 2, Fig. 3) from an initial pool of 16 compounds. As demonstrated by an iodid...
Heat shock protein (HSP) 90, an important component of the molecular chaperone network, is closely concerned with cellular signaling pathways and stress response by participating in the process of maturation and activation of client proteins, playing a c
We selected a tumour cell model to investigate the previously raised questions, based on the fact that the best-characterized oncogene that triggers Hsp90α secretion is hypoxia-inducible factor-1 alpha (HIF-1α), which is overexpressed in more than 50% of all invasive tumours in humans35. ...
Degradation of HIF-1alpha under Hypoxia Combined with Induction of Hsp90 Polyubiquitination in Cancer Cells by Hypericin: a Unique Cancer Therapy. The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting d.....
HIF-1α: Hypoxia-inducible factor 1 HSF-1: Heat shock factor 1 HSP70/90: Heat shock protein 70/90 IRE1α: Inositol-requiring enzyme 1 alpha MCL-1: Myeloid cell leukemia-1 MEK1/2: Mitogen-activated protein kinase 1/2 mTOR: Mechanistic target of rapamycin kinase ...
Heat-shock-protein 90 protects from downregulation of HIF-1alpha in calcineurin-induced myocardial hypertrophy. J Mol Cell Cardiol. 2015;85:117–26. Article CAS Google Scholar Marunouchi T, Nakashima M, Ebitani S, Umezu S, Karasawa K, Yano E, et al. Hsp90 inhibitor attenuates the ...