Hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol. Cell. Biol. 9, 3919–3930 (1989). CAS PubMed PubMed Central Google Scholar Shen, Y. et al. Essential role of the first intron in the transcription of hsp90βgene....
Inhibition of the recombinase Rad51, a downstream target of Hsp90, induces a comparable increase in repeat instability, suggesting that Hsp90-enabled homologous recombination normally functions to stabilize CAG repeat tracts. By contrast, Hsp90 inhibition does not increase the rate of gene-inactivating...
Gene ID 3326 SwissProt P08238 Synonyms Heat shock 90KD protein 1 beta; HS90B; HSP90B; HSP90 beta; HSPCB; HSPC2; HSP 90b; HSP84 Category Protein Folding and Trafficking Background Hsp90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and ...
A. Hsp90: a chaperone for protein folding and gene regulation. Biochem. Cell Biol. 83, 703–710 (2005). Article CAS PubMed Google Scholar Gong, Y. et al. An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol. ...
Two isoforms which correspond to the major and minor isoform , (Hsp90 α and Hsp90 β ) can be found in nearly equal amount in humans, and operates as part of a multichaperone machinery in the cytosol, which includes Hsp70, peptidyl-prolyl isomerases and other cochaperones. 包装清单: ...
Leishmania parasites cause severe illness in humans and animals. They exist in two developmental stages, insect form and mammalian form, which differ in shape and gene expression. By mapping and quantifying RNA fragments protected by protein synthesis complexes, we determined the rates of protein ...
Gene ID3326 SwissProtP08238 SynonymsHeat shock 90KD protein 1 beta; HS90B; HSP90B; HSP90 beta; HSPCB; HSPC2; HSP 90b; HSP84 CategoryProtein Folding and Trafficking BackgroundHsp90 are molecular chaperones expressed constitutively under normal conditions to maintain protein homeostasis and are indu...
2C). These results demonstrated that the fast growth of yeast cells correlated with the presence of the middle domain of the Hsp90 β in the analyzed hybrid gene. To narrow down this region, we analyzed hybrids in which only half of the middle domain was replaced (H11 and H12). The ...
Hsp90 inhibitor is associated with reduced miRNA and short inter- fering RNA-dependent gene silencing.24 Below, we describe several signaling pathways involving Hsp90. Connexin 43 (Cx43) is essential for the survival of cells. The expression of Cx43 is increased in ras-transformed cells, being...
Hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol. Cell. Biol. 9, 3919–3930 (1989). Article CAS PubMed PubMed Central Google Scholar Swoboda, R. K. et al. Structure and regulation of the HSP90 gene from the ...