HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular Targeted Cancer TherapyHSP90 inhibitorcancertargeted therapytumor biomarkerclient proteinHeat shock protein 90 (HSP90), a highly and unique chaperone, presents as a double-edged sword. It plays an essential role in ...
2017. An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans. Nat Commun 8:15328. https://doi.org/10.1038/ncomms15328.Zuehlke, A. D., M. Reidy, C. Lin, P. LaPointe, S. Alsomairy et al., 2017 An Hsp90 co-chaperone...
The structure of a HOP–TPR–peptide complex explains how TPR domains participate in the assembly of the HSP70–HSP90 multichaperone complex. Article CAS PubMed Google Scholar Schmid, A. B. et al. The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J. 31, ...
In an Extra Views publication by Eustace and Jay (Cell Cycle 2004; 3:1096-1098), we reported that the co-chaperone Hsp70 was not found in the conditioned media of HT-1080 fibrosarcoma cells grown in culture (Figure 1). We have since discovered that this finding is in error. We ...
Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperonesdoi:10.1007/s00294-014-0432-3Molecular chaperonesHsp90Tetratricopeptide repeat proteinsCo-chaperonesSaccharomyces cerevisiaeThe essential molecular chaperone Hsp90 functions with over ten...
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J Biol Chem. 2002; 26 :20151–20159. 0021-9258(2002)0262.0.CO;2 [ PubMed ]Siligardi G, Panaretou B, Meyer P, Singh S, Woolfson DN, et al. (2002) Regulation of Hsp90 ATPase activity by the co-chaperone ...
Heatshockprotein90(HSP90)isamolecularchaperonethatisinducedinresponsetocellularstressandstabilizesclientproteinsinvolvedincellcyclecontrolandproliferative/anti-apoptoticsignalling.Hsp90expressionthatquantityisnormalcellsof2~8times,andmaycontributetotumourcellsurvivalbystabilizingaberrantsignallingproteinsandbyinterferingwith...
Hsp90 co-chaperone Progesterone receptor complex p23 Telomerase-binding protein p23 种属::Homo sapiens (Human) 蛋白长度::Full length 来源::Yeast 分子量::20.7 kDa 表达区域::1-160aa 氨基酸序列:MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSV...
(2004) Functional specificity of co-chaperone interactions withhsp90 client proteins. Rakitina, TV, and O'Dwyer, PJ (2004) Quantitative effects on c-Jun N-terminalprotein kinase signaling determine Assembly of the reovirus cell attachment protein. ...
anHsp90cochaperone,intheamphioxusBranchiostomabelcheri ZHAOBosheng 1,2 ,ZHANGShicui 1! ,PANGiuxiang 1,2 , L UZhenhui 1 ,L ANGYujun 1 1.DepartmentofMarineBioIogy,OceanUniversityofChina,ingdao266003,China 2.SchooIofLifeSciences,ShandongUniversityofTechnoIogy,Zibo255049,China Received13May2006;accepte...