Here, we show that in mammals, the cytosolic chaperones Hsp90 and Hsp70 dock onto a specialized TPR domain in the import receptor Tom70 at the outer mitochondrial membrane. This interaction serves to deliver a set of preproteins to the receptor for subsequent membrane translocation dependent on ...
Two of the components, FKBP52 and p23, functioned as mechanistically distinct molecular chaperones. These results suggest the existence of a super-chaperone complex in the cytosol of eukaryotic cells. 展开 关键词: Heat shock proteins Endoplasmic reticulum Molecular chaperones. Hsp90 Receptor ...
Hsp104 cooperates with the chaperones present in reticulocyte lysates but not with DnaK of E. coli. We conclude that Hsp104 has a protein remodeling activity that acts on trapped, aggregated proteins and requires specific interactions with conventional chaperones to promote refolding of the ...
Molecular chaperones are a functionally defined set of proteins which assist the structure formation of proteins in vivo. Without certain protective mechanisms, such as binding nascent polypeptide chains by molecular chaperones, cellular protein concentrations would lead to misfolding and aggregation. In th...
To combat protein damage, cells contain large families of proteins, named chaperones, which assist in protein folding and repair. So far, only a minority of these proteins have been studied and the largest chaperone family in humans consists of the HSP70/HSP40 family. In this thesis, the ...
Hsp70 chaperones: cellular functions and molecular mechanism. Cell. Mol. Life Sci. 62, 670–684 (2005). CAS PubMed PubMed Central Google Scholar Kampinga, H. H. & Craig, E. A. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat. Rev. Mol. Cell Biol....
热休克蛋白(heat shock proteins, HSPs)是细胞在应激原诱导下产生的,如缺氧、氧化损伤和高温等[1]。Hsp90是一种高度保守的分子伴侣蛋白,在300多种候选蛋白底物的组装、功能成熟、运输、折叠和降解中发挥重要作用,包括各种蛋白激酶、类固醇激素受体、突变的P53、生存素和其他通过与共伴侣相互作用而导致失控增殖和凋亡抵...
Heat shock proteins (Hsps) perform a fundamental role in protecting plants against abiotic stresses. Although researchers have made great efforts on the functional analysis of individual family members, Hsps have not been fully characterized in rice (Ory
展开 关键词: Saccharomyces cerevisiae Cytoskeletal Proteins Saccharomyces cerevisiae Proteins Recombinant Fusion Proteins Heat-Shock Proteins Molecular Chaperones Oxidation-Reduction Protein Carbonylation Actins Microtubule-Associated Proteins DOI: 10.1128/MCB.00201-09 被引量: 143 年份...
Heatshockproteinsarealsopresentincellsunderperfectlynormalconditions.Theyactlike“chaperones”,makingsurethatcell’sproteinsareintherightshapeandintherightplaceattherighttime.注：Chaperone：伴侣，指热休克蛋白具有分子伴侣活性：伴侣，译文：细胞在正常情况下也存在热休克蛋白。译文：细胞在正常情况下也存在热休克蛋白...