In another study patients with specific chronic diseases also showed higher HRQoL values for mental components with increased age while those of physical components were poorer [31]. In terms of sex, there are different findings in general populations, mostly showing lower HRQoL values reported by ...
Our culture tends to think about illness in terms of a familiar medical narrative moving from catalyst to crisis to cure. The catalyst is what triggers or sets off the unwellness in the first place. The crisis is the experience (or representation of the experience) of the unwelln...
As well as being of interest in itself, this phenomenon is evidently of importance in medical terms, since it may be possible to achieve a therapeutic benefit in diseases such as stroke or cardiac ischaemia by inducing HSP over-expression either pharmacologically or using gene delivery procedures....
usually appear during late childhood. Genome-wide molecular studies on a subset of carefully chosen, undiagnosed PME cases can add to our understanding of the underlying genetic heterogeneity, in addition to the 80% who have already received an etiologic diagnosis. Whole-exome sequencing (WES) iden...
2020), and researchers have also identified the milestone manuscripts, active authors, and influential institutions in their research field. We employed WoS Core Collection (WoSCC) database to search for relevant publications on HSPB5 using the terms “HSPB5” or “αB crystallin” from WoSCC ...
trametinib (Fig.3h, i), whereas it induced an MET in A549 cells (Supplementary Fig.6C). In line with these results, analyzing gene ontology terms and TCGA data significantly associatedATF2with EMT,PERKwithATF2andJNKbut not withMAPK14(p38) inKRAS-mutant lung cancer (Supplementary Fig.6D–F...
National Institute for Health and Care Research's Cambridge Biomedical Research Centre, along with the Medical Research Council Newton Fund, the Ministry of Science and Technology, the Wellcome Trust, the Academy of Medical Sciences, and the Health Foundation, are crucial for progress in medical ...
As the blunted HRS is similar in critically ill patients with COVID-19 (with or without diabetes) and noninfected patients with diabetes, we may state that diabetes induces similar responses in terms of HSP72 and the HSR systems that severe COVID-19 (by different mechanisms) induces. In ...
[4]. The fungal cells released from a matured biofilm appear to be highly virulent compared to planktonic cells in terms of systemic candidiasis development [45,46] and Hsp90 also plays an important role in biofilm dispersions [44,47]. Since we could find the overexpression of Hsp90 and ...
In addition, p23 directly stabilizes native GR using a C-terminal helix, resulting in enhanced ligand binding. This structure of a client bound to Hsp90 in a native conformation contrasts sharply with the unfolded kinase–Hsp90 structure11. Thus, aided by direct co-chaperone–client interactions...