Our culture tends to think about illness in terms of a familiar medical narrative moving from catalyst to crisis to cure. The catalyst is what triggers or sets off the unwellness in the first place. The crisis is the experience (or representation of the experience) of the unwelln...
usually appear during late childhood. Genome-wide molecular studies on a subset of carefully chosen, undiagnosed PME cases can add to our understanding of the underlying genetic heterogeneity, in addition to the 80% who have already received an etiologic diagnosis. Whole-exome sequencing (WES) iden...
This report addresses the range of diagnostic possibilities and subsequent management strategies associated with this infrequent medical condition.Adenoviral pseudomembranous conjunctivitis, while typically resolving on its own with supportive care, can, in a small subset of cases, lead to severe inflammation...
As well as being of interest in itself, this phenomenon is evidently of importance in medical terms, since it may be possible to achieve a therapeutic benefit in diseases such as stroke or cardiac ischaemia by inducing HSP over-expression either pharmacologically or using gene delivery procedures....
2020), and researchers have also identified the milestone manuscripts, active authors, and influential institutions in their research field. We employed WoS Core Collection (WoSCC) database to search for relevant publications on HSPB5 using the terms “HSPB5” or “αB crystallin” from WoSCC ...
trametinib (Fig.3h, i), whereas it induced an MET in A549 cells (Supplementary Fig.6C). In line with these results, analyzing gene ontology terms and TCGA data significantly associatedATF2with EMT,PERKwithATF2andJNKbut not withMAPK14(p38) inKRAS-mutant lung cancer (Supplementary Fig.6D–F...
The molecular chaperone heat shock protein 90 (HSP90) regulates multiple crucial signalling pathways in cancer by driving the maturation of key signalling
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Share and Cite MDPI and ACS Style Bourefis, A.; Berredjem, H.; Djeffal, O.; Le, T.K.; Giusiano, S...
As the blunted HRS is similar in critically ill patients with COVID-19 (with or without diabetes) and noninfected patients with diabetes, we may state that diabetes induces similar responses in terms of HSP72 and the HSR systems that severe COVID-19 (by different mechanisms) induces. In ...