Suddenly, she was living among strangers, fighting in crowds for courses and books, and always overstimulated... Kristen was on the edge” [1] “Kristen” was one of psychologist Elaine Aron’s interviewees who would qualify as a “highly sensitive person,” or HSP—a term Aron...
However, all could be grouped together via EFA and were identified as important symptoms in HSP patients. The positive correlations to EQ-5D-5L – an already well-validated HRQoL questionnaire were all significant except for the medical care subdomain, supporting the validity of TreatHSP-QoL. ...
1998). The term “αB-crystallinopathies” was coined for the pathology caused by HSPB5 mutations (Dimauro et al. 2018; Sharma and Goebel 2005). Neurodegenerative disease is a type of disease caused by progressive loss of structure or function of the body’s neurons, including AD, ...
HSP90 is moderately overexpressed in drug-resistant relative to parental cells, but HSP90 inhibition with onalespib (0.5 µM) selectively induced apoptosis in resistant cells only, marked by dramatic increase of cleaved poly(ADP-ribose) polymerase (Cl PARP) and caspase 7 (Cl Cas7) at 24...
Employing microfluidicflow chambers in combination with optical tweezers and fluorescent microscopy,we elevated the influx of arsenite into the yeast Saccharomyces cerevisiae cells following short-term treatment witha Hog1 kinase inhibitor. The increase in arsenite uptake was followed onarsenite triggered ...
. Overall, neurite length in patient neurons was drastically decreased by 51% (control: 60.6 ± 11.1 µm; SPG4: 29.4 ± 5.4 µm; Fig.2D). Figure 2 Short-term read-out of neurite outgrowth, growth cone formation and axonal swellings in iPSC-derived cortical neurons...
-term and long-term memory tests. A decrease in the NMDAR-AKT transduction complex is observed in the postmortem brain tissue of individuals experiencing early Alzheimer's disease. Arc, a novel mediator of synapse-specific NMDAR-AKT signaling and metaplasticity, contributes to memory updating and ...
A 6-year treatment experience for pemphigus: retrospective study of 69 Chinese patients.###Subcutaneous injection of thymopentin in the area of the supram... There is a lack of data on treatment and prognosis of pemphigus in China. The aim of this study was to evaluate long-term follow-up...
The spectrum of myelin oligodendrocyte glycoprotein antibody-associated diseases (MOGAD) has demonstrably increased in the last ten years. The recent medical literature includes accounts of patients diagnosed with MOG antibody encephalitis (MOG-E) who fail to meet the established criteria for acute disse...
HSP与CSP治疗大肠息肉的效果及安全性的回顾性对照分析