Adults (⩾18 years) with a confirmed diagnosis of MM by International Myeloma Working Group (IMWG) criteria (Durie et al, 2006; Kyle and Rajkumar, 2009), who had relapsed or failed to respond at least one prior MM regimens with an Eastern Cooperative Oncology Group (ECOG) performance statu...
Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be assi
In our previous study, we demonstrated that Eno promotes the expression of host heat shock protein family D member 1 (HSPD1); Eno-HSPD1 interaction induces apoptosis of porcine brain microvascular endothelial cells (PBMECs), resulting in impairment and increased permeability of the BBB, and pro...
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias. Blood 2006, 109, 2781–2790. [CrossRef] [PubMed] 46. Robertson, F.M.; Woodward, W.; Pickei, R.; Ye, Z.; Bornmann, W.; Pal, A.; Peng, Z.; ...