HSF1 TAD的功能仍然很大程度上没有表征,但已显示Hsp70与该结构域结合,这可描述Hsp70负调节HSF1的机制。磷酸化热休克因子-1兔单克隆抗体是将Phospho-9HSF1(Ser326)作为抗原注入兔体内进行免疫程序后在兔血清中纯化制得的抗体。 临床应用[5][6] Phospho-HSF1(Ser326)Rabbit Monoclonal Antibody可作为以Phospho-9HS...
CAS号: 英文名: Phospho-HSF1 (S326) Antibody 英文别名: Phospho-HSF1 (S326) Antibody 中文名: 中文别名: CBNumber: CB95672946 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 4 Phospho-HSF1 (S326) Antibody化学性质...
抗体名: HSF1 (phospho S326); p-HSF1 (phospho S326); Heat shock factor 1; Heat shock factor protein 1; Heat shock transcription factor 1; HSF 1; hsf1; HSTF 1; HSTF1; HSF1_HUMAN.靶点: 详见说明书 宿主: Rabbit 适应物种: 详见说明书 ...
Phospho-CDC37 (Ser13) Antibody (YA219) Phospho-HSF1 (Ser326) Antibody(YA894) Hsf2 Antibody (YA2235) GRP94 Antibody (YA2519) Hsp47 Antibody (YA2608) Hsp75 Antibody (YA2625) Phospho-HSF1 (Ser303/Ser307) Antibody HSF1 Antibody (YA896) ...
show Hsf1, non-phospho (active) β-catenin (Ser33/37/Thr41), β-catenin, YAP, TAZ, pS19-MLC2 (pMLC2) and Tubulin in murine CAF1 and CAF5 after transfection with control (siCtr) or Hsf1 (smart-pool) siRNAs.jGraph shows gel contraction of CAF-WT, CAF-KO.9-REC and CAF-KO.9...
(9422), Bcl-xl (2764) and HER2 (29D8; all for human and mouse, Cell Signaling), phospho-Ser326 HSF1 (human, ADI-SPA-902, ENZO, Lörrach, Germany), Hsp27 (G31, Cell Signaling), Hsp90α (human and mouse, Millipore), and Gapdh (8245) and actin (8227; both Abcam, Cambridge,...
Whole cell protein extract preparation and western blot were performed as described previously [45]. For phospho-specific detection of HSF1, α-pS326 HSF1 (Abcam, ab76076; dilution 1:2000) and α-GAPDH (Santa Cruz, sc-25778; dilution 1:5000) were used as primary antibodies. Primary antib...
In human and mouse HER2-overexpressing breast cancer systems in vitro and in vivo, we show that inhibiting HER2/ErbB2 leads to inhibition of phosphoactivated Ser326 HSF1, and subsequently blocks the activity of the HSP90 (and Cell Death and Disease likely the HSP27) chaperone machinery. This...
Similarly, HSF1 regulates hepatic mitochondrial biogenesis and mitochondrial respiration through nicotinamide phosphoribosyltransferase (NAMPT) and the nicotinamide adenine dinucleotide (NAD+) salvage pathway [25]. Interplay between HSF1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (...