GDL通过调节HSF1/HSPB1通路抑制铁死亡,改善TX小鼠的肝损伤。 GDL可以促进TX小鼠的HSF1和HSPB1表达,通路抑制剂NXP800降低了HSF1和HSPB1的表达。此外,与GDL组相比,NXP800显著消除了HSF1、HSPB1和FTH1的蛋白质和mRNA水平,同时提高了...
HSP可能在应激中对行为产生影响,如:应激可以诱发和加重抑郁,有研究发现: 抑郁症患者尸体前额叶基因谱尸检发现HSPFl表达改变,在重症抑郁与自杀患者 的淋巴母细胞中也发现了相似的异常,提示HSP70可能通过维持细胞存活,在调 节情绪障碍中发挥重要作用闭.采用HSF70鼻内注射的方法探讨HSP70对于不可 逃避应激后的适应不良行为...
At selected times (0, 1, 3, and 24 hours) after a 10-minute, 41C heat stress, fast (white gastrocnemius [WG]) and slow (soleus) skeletal muscles were examined for either heat shock transcription factor (HSF) activation (trimerization and DNA-binding activity) or Hsp72 content using...
内容提示: 密级: 论义编号:中国农业科学院学位论文热激转录因子(Hsf)与热激蛋白基因(Hsp70、Hsp21、sHsp21)在莲草直胸跳甲高温耐受性中的作用The Roles of Heat Shock Transcription Factor(//sf)and HeatShock Protein Gene(Hsp 70,Hsp21,sHsp2 1)on the High7Iemperature Tolerance of Agasicles hygro...
Hsf,sHsp,Hsp60,Hsp70, andHsp100families ofP. trichocarpawere 28, 37, 28, 20, and 5, respectively (Table1). The subcellular localization predictions suggested that the PtHsfs are targeted to the nucleus, while PtHsps are localized to various cytosolic organelles. Detailed information on theHsf...
第一部分HSF1/HSP在慢性心理应激中对海马及海马依赖功能的保护作用 目的探讨热休克因子1(heat shock factor 1,HSF1)及热休克蛋白(heat shock protein,HSP)在慢性心理应激中对小鼠海马及海马依赖的情绪行为和空间工作记忆的保护作用及其机制. 方法HSF1基因野生型小鼠(简称:HSF1+/+小鼠)共56只,HSF1基因敲除小鼠(简...
Finally, we demonstrate that Hsp90 regulates global transcription programs by modulating nucleosome levels at promoters of stress-responsive genes. Thus, we describe a mechanism by which C. albicans responds to temperature via Hsf1 and Hsp90 to orchestrate gene expression and chromatin architecture, ...
thereby scaling the amount of total protein. These adaptations render them more resilient to persistent and subsequent stresses. We demonstrate that Hsf1, well known for its role in acute stress responses, is required for the cell size increase, and that the molecular chaperone Hsp90 is essential...
HSF1A 是一种可渗透细胞的 HSF1 激活剂,可保护哺乳动物细胞免受应激诱导的细胞凋亡。它还是 TRiC/CCT 的特异性抑制剂。 规格价格库存数量 1 mg¥ 549现货 5 mg¥ 987现货 10 mg¥ 1,490现货 25 mg¥ 3,230现货 50 mg¥ 4,630现货