Cell-cycle status is essential for regulation of this balance, by which long-term (LT)-HSCs are preserved in a quiescent state for maintenance whereas short-term (ST)-HSCs and multipotent progenitor (MPP) cells are fast cycling for increasing cell mass and further differentiation (Yang et al....
Genes defining this principle component define the progression from CMP to GMP to granulocyte (Figures S4F and S4G). Given the alterations in transcriptional output and differentiation potential, we hypothesized that Stag2 loss led to altered chromatin accessibility at differentially expressed loci. We...
CLP, common lymphoid progenitors (Lin−CD11c−CD27+IL7r+Flt3+Ly6d−); CMP, common myeloid progenitors (Lin−Sca1−Kit+CD16/32−CD34+); GMP, granulocyte-macrophage progenitors (Lin−Sca1−Kit+CD16/32+CD34+); MEP, megakaryocyte-erythrocyte progenitors (Lin−Sca1−Kit+CD16/...
To investigate whether the proliferation of hematopoietic cells was affected by p57 deficiency, cell cycle progression was examined in fetal liver (FL) LSK cells, common lymphoid progenitors (CLP), common myeloid progenitors (CMP), granulocyte-macrophage progenitors (GMP), and megakaryocyte-erythroid pr...