2023, Experimental Hematology Citation Excerpt : The elucidation of mechanisms underlying EHT is critical for generating functional HSCs in vitro for clinical applications [90–93]. During EHT, endothelial cells undergo a series of molecular and cellular changes, enabling them to differentiate into HSCs...
Discussion Understanding the regulatory mechanism of PD-L1 is crucial for developing more cancer immunotherapy strategies. Recent studies have uncovered that after aPD-L1 treatment, the induction of intracellular PD-L1 and the subsequent re-expression to the cell membrane31,32,33. This mechanism confer...
2023, Blood Citation Excerpt : Histological analyses of liver and spleen tissues from prime edited CD46/Townes mice showed normal architecture with largely regressed parenchymal iron deposition and extramedullary hemopoiesis (Figure 5E), in sharp contrast to untreated CD46/Townes tissue sections. Splenome...
Article Open access Published: 05 September 2023 The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70 Lorea Velasco-Carneros, Jorge Cuéllar, Leire Dublang, César Santiago, Jean-Didier Maréchal, Jaime Martín-Benito, Moisés ...
Discussion Our previous study found that diosgenin significantly restored the Aβ-induced axonal atrophy and memory deficits in 5XFAD mice2. This study investigated the key signaling of diosgenin. By using 2D-PAGE analysis, we comprehensively explored proteins whose expression level was changed in the...
Additionally, HSC70 has been detected in extracellular vesicles, notably within exosomes derived from highly purified human B cells (Xiong et al., 2023). HSC70, a protein with multiple domains, exhibits intrinsic conformational diversity and the ability to interact with many ligands, contributing to...
Volume 31, Issue 4, 5 April 2023, Pages 1059-1073Original ArticleStable HIV decoy receptor expression after in vivo HSC transduction in mice and NHPs: Safety and efficacy in protection from SHIV Author links open overlay panelChang Li 1 7, Anna Kate Anderson 1, Hongjie Wang 1, Sucheol ...
2023, Blood Citation Excerpt : Pathway analysis was performed with Reactome,43 Generally Applicable Gene-set Enrichment44 or Gene Set Enrichment Analysis.45 The IFN-1 target gene set was previously described in the study by Li et al.30 ATAC-seq and ChIPmentation libraries were generated and anal...
2023, Acta Pharmaceutica Sinica B Citation Excerpt : NVS-HD1 (27) shares the same ZBG (trifluoromethyloxadiazole, TFMO) with TMP269 (26), but it is more potent and selective than TMP269 (26). As the most potent and selective class IIa HDACs inhibitor, NVS-HD1 (27) displayed very high...