HSC 2014 BIOLOGY QUESTION PAPERWWOM
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2024, Trends in Cell Biology Citation Excerpt : However, there must be an increase in the number of HSCs in fetal liver, and it is unclear how they undergo expansion (self-renewal) and differentiation in such a short time (3–4 days after HSC emergence). Recent studies have shown that ...
To address this question, we first analysed the holding activity of the DNAJA2 variants using as substrate proteins tau K18P301L and luciferase. In the first case, DNAJA2ΔG/FR, DNAJA2ΔZFLR and DNAJA2LQ had a protecting role similar to DNAJA2wt (Fig. 5a). In contrast, DNAJA2Δ...
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The discrepancy between in vitro and in vivo responses to IL-1β raised the question of whether this reflects differences in proliferation status. HSCs cycle in culture, but they are usually quiescent in the adult bone marrow. To test this, we treated Fgd5-CreER; Kmt2cf/+ mice with tamoxi...