如图3a所示,miR-377-3p和hsa_circRNA_103809之间存在潜在的碱基配对(标记为红色)。此外,miR-377-3p上调抑制了hsa_circRNA_103809报告质粒的荧光素酶活性(图3b),而miR-377-3p结合位点突变时荧光素酶活性没有显著变化。miR-377-3p和hsa_circRNA_103809在RNAs中显著富集(图3c),可被Ago2抗体沉淀。鉴于Ago2是miRNA介...
Hsa_circRNA_103809 was found to be significantly down regulated in CRC tissues and cell lines and compared with paired adjacent non-tumorous tissues and normal FHC cells. Hsa_circRNA_103809 participates in the regulation of biological functions through the miR-532-3P/FOXO4 axis in the CRC. Hsa_...
Analysis of data suggested that targeting the hsa_circRNA_103809/miR-377-3p/GOT1 pathway increased susceptibility of CR-NSCLC cells to cisplatin, and this study provided novel targets to improve the therapeutic efficacy of cisplatin for NSCLC treatment in clinic....