The hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p were significantly up-regulated in plasma of SLE patients (P = 0.048, P = 0.039, and P = 0.046, respectively). Especially, the hsa-miR-223-3p was significantly associated with oral ulcer (P P = 0.031). Thus, plasma hsa-...
The hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p were significantly up-regulated in plasma of SLE patients ( P = 0.048, P = 0.039, and P = 0.046, respectively). Especially, the hsa-miR-223-3p was significantly associated with oral ulcer ( PB.‐S. Kim...
最终确定hsa-miR-92a-3p的靶基因集合范围.然后通过string11.5构建所预测靶基因集合编码蛋白质间的相互关系网络图.最后通过DAVID和KOBAS3.0公共数据库对所预测的靶基因交集进行功能富集分析(GO分析)和信号转导通路富集分析(KEGG分析).结果:筛选出192个hsa-miR-92a-3p的靶基因,PTEN,ITPR1,MAPK8,FBXW7,KAT2B,SMAD7...