促进肝癌干细胞自我更新的癌基因hsa-mir-449a,核苷酸序列如seqidno:1所示。 hsa-mir-449a目前认为其为抑癌基因可以阻断肿瘤的发生发展,但是发明人在研究过程中意外发现hsa-mir-449a在肝癌干细胞中表达可以作为癌基因,促进肝癌的发生发展。 进一步,本发明提供了hsa-mir-449a的新用途。hsa-mir-449a基因在抑制肝癌...
(GSE61741: miR-449a, FC = 2.7,p-value = 0.0005). Contrary to our results, miR-200c was found to be downregulated in one case (GSE61741: FC = 0.59,p-value = 0.002). Moreover, miR-320 family was overexpressed (p-value = 0.018) in COPD patients (GSE70080: miR-320b, FC = ...