本发明属于小分子RNA应用技术领域,公开了hsamiR320a在针对细胞迁移抗肿瘤药物中的应用.hsamiR320a核苷酸序列为:5'AAAAGCUGGGUUGAGAGGGCGA3',其中5'AAAGCUG3'为小分子RNAhsamiR320a的种子区序列.本发明表明hsamiR320a通过其靶基因DAB2参与了Hela肿瘤细胞迁移的调控,靶基因和hsamiR320a可作为肿瘤细胞中的调控分子...
5.根据权利要求4所述的药物,其特征在于,所述药物的药效成分为所述药物的药效成分为重组腺相关病毒质粒pAAV-D(+)-anti-miR-320a,其表达的序列片段anti-hsa-miR-320a与hsa-miR-320a反义互补。 更具体地,所述pAAV-D(+)-anti-miR-320a是通过将序列如SEQ ID NO.4和SEQ IDNO.5所示的引物对插入至腺病毒...
基于hsa-miR-320a的防治糖尿病的药物及其筛选方法和制备方法[发明专利]
本发明“基于hsa‑miR‑320a的糖尿病早期预警和/或诊断试剂盒的制备方法”,属于分子医药及代谢性疾病的诊断、预防和治疗领域。用于诊断和/或早期预警糖尿病的生物标志物包括:含有hsa‑miR‑320a在内的序列片段;所述hsa‑miR‑320a如SEQ ID No.1所示。所述用于诊断和/或早期预警糖尿病的试剂盒包... ...
hsa-miR-320a在针对细胞周期抗肿瘤药物中的应用本发明属于小分子RNA应用技术领域,公开了常氧条件下hsamiR320a在针对细胞周期抗肿瘤药物中的应用.所述hsamiR320a为一种小分子RNA,其核苷酸序列为:5'AAAAGCUGGGUUGAGAGGGCGA3',其中5'AAAGCUG3'为hsamiR320a的种子区序列.本发明构建DAB2和RBM24的过表达载体,肿瘤...
本发明"基于hsamiR320a的防治糖尿病的药物及其筛选方法和制备方法",属于分子医药及代谢性疾病的诊断,预防和治疗领域.所述药物的药效成分以hsamiR320a为药物靶点,且通过结合,和/或捕获,和/或降解,和/或下调表达所述hsamiR320a起到所述防治糖尿病的药效;所述hsamiR320a如SEQ ID NO.1所示.同时本发明还提供了所...
Here, we report that engineered exosomes-mediated transfer of hsa-miR-320a overcomes chemoresistance in cervical cancer cells via targeting Myeloid Cell Leukemia Sequence 1 (MCL1). In DDP resistant CC tissues, as well as cell lines, it was found that miR-320a expression is lo...
Ebola virus infection, human Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p and predicted targets problematicPATHOGENESISeditorAFRICAShengRESPONSIVEUmbilicalconservedmentionedmiRNAsTo the editor,Sir,the present problematic Ebola virus(HBOV)infectionin Africa is the global concern.The pathogenesis and ...
Hsa-miR-320a mimics reduced luciferase activity in PCa cells transfected with WT-LINC01518/CNKSR2plasmids. Knocking down LINC01518 reduced CNKSR2 level, and this regulatory effect disappeared with the inhibition of hsa-miR-320a.#High levels of LINC01518 predicted poor prognosis in PCa patients ...
hsa-miR-320a在针对细胞周期抗肿瘤药物中的应用本发明属于小分子RNA应用技术领域,公开了常氧条件下hsamiR320a在针对细胞周期抗肿瘤药物中的应用.所述hsamiR320a为一种小分子RNA,其核苷酸序列为:5'AAAAGCUGGGUUGAGAGGGCGA3',其中5'AAAGCUG3'为hsamiR320a的种子区序列.本发明构建DAB2和RBM24的过表达载体,肿瘤...