进一步实验研究发现miR-27a-3p过表达抑制了细胞增殖,迁移,而miR-27a-3p过表达后上调Fbxw7恢复了细胞增殖,迁移能力,说明miR-27a-3p具有抗肿瘤作用,且Fbxw7是miR-27a-3p的下游靶点.结论hsa_circ_0070260通过吸附miR-27a-3p来促进Fbxw7表达是导致乳腺癌细胞增殖,迁移的重要原因,靶向hsa_circ_0070260对乳腺癌细胞...
TNF-α initiates psoriatic inflammation by increasing CXCL-1/8 in keratinocytes mediated by the axis of NF-κB-hsa-miR-27a-3p-galectin-3 pathway.View further author informationwliangch@mail.sysu.edu.cnLiang-chun WangView further author information...