(4)结合公共生物信息学网站发现hsa-miR-224-3p可能为PD-L1的调控上游,可作进一步研究.(5)q RT-PCR结果显示,AB组织中hsa-miR-224-3p相对表达量明显降低,差异显著(P<0.05).(6)双荧光素酶验证报告结果显示hsa-miR-224-3p与PD-L1存在结合位点,可靶向调控PD-L1.(7)q RT-PCR结果显示,转染hsa-miR-224-3p ...
接下来,数据库预测了hsa_circ_0004872的潜在靶miRNAs,发现只有hsa-miR-224(miR-224)具有致癌功能。RNA pull-down和双荧光素酶报告基因实验均表明hsa_circ_0004872与miR-224相互作用。 3. hsa-circ-0004872通过miR-224上调其靶标p21和Smad4的表达 过表达/干扰和细胞实验表明miR-224促进胃癌的细胞增殖、侵袭和迁移。
et al. FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report. BMC Med Genomics 16, 21 (2023). https://doi.org/10.1186/s12920-023-01450-w Download citation Received29 April 2022 Accepted01 February...
Our collective findings advised that hsa_circ_0017639 takes part in GC progression through regulating the miR-224-5p/USP3 axis, highlighting its potential as an effective GC therapeutic target. 展开 关键词: Hsa_circ_0017639 Gastric cancer Sponge miR-224-5p USP3 ...
Besides, the circFGFR1-induced regulation in glioma malignancy is also abrogated in hsa-miR-224-5p knockout cells. Taken together, our findings suggest that circFGFR1 plays a critical role in the tumorigenic behaviors in glioma cells by upregulating CXCR4 expression via sponging to hsa-miR-224-...
BMC Medical Genomics (2023) 16:21 https://doi.org/10.1186/s12920-023-01450-w BMC Medical Genomics RESEARCH Open Access FZD1/KLF10‑hsa‑miR‑4762‑5p/ miR‑224‑3p‑circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report ...
FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive reportPROGNOSISCIRCULAR RNADRUG targetGLIOBLASTOMA multiformeMESSENGER RNAWNT signal transductionBackground: The circular RNA (circRNA) plays a vital role in the ...