[目的]以人脐静脉内皮细胞(HUVECs)为糖尿病肾病(DKD)体外模型,通过研究高糖刺激下hsa-miR-223-3p在内皮细胞中的变化,明确hsa-miR-223-3p与预测靶基因IL6ST,PRKCE间的关系,探究hsa-miR-223-3p与预测靶基因下游通路的变化与高糖刺激间的关系,从而间接探究DKD发病机制中hsa-miR-223-3p变化与内皮损伤间的关联...
The hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p were significantly up-regulated in plasma of SLE patients ( P = 0.048, P = 0.039, and P = 0.046, respectively). Especially, the hsa-miR-223-3p was significantly associated with oral ulcer ( P...
Therefore, plasma hsa-miR-223-3p is a novel biomarker for the severity in Different Stages of DKD in China.doi:10.2337/DB18-512-PJunyi HeRong LiLan LiYanan WuQiuping YangLihua ZhangAmerican Diabetes AssociationDiabetes
Especially, the hsa-miR-223-3p was significantly associated with oral ulcer (P P = 0.031). Thus, plasma hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p may be promising novel biomarkers in the diagnosis and clinical manifestation of SLE.B.-S. Kim...
Conclusion * Hsa-miR-223-3p may participate in a variety of biological processes through target genes, and the hub gene PRKACB may provide assistance for exploring the pathogenesis of DM.YU Meng-naYANG BiaoYANG Li-zhenJournal of Shanghai Jiaotong University (...
川崎病目的研究hsa-miR-223-3p和hsa-miR-33b-3p在川崎病患儿外周血中表达的意义.方法选取2018年6月-2019年5月永康市中医院和浙江大学医学院附属儿童医院收治的川崎病患儿8例为观察组,同期在该院体检的健康儿童8例为对照组.提取两组研究对象血浆中总RNA,采用miRNA芯片杂交技术检测两组研究对象差异表达的miRNAs,...
·共筛选出870个hsa-miR-223-3p靶基因.GO,KEGG和Reactome富集分析显示,靶基因主要与RNA聚合酶Ⅱ启动子的调节,细胞对胰岛素刺激的反应,RNA结合等相关,且主要富集于胰岛素分泌,泛素介导的蛋白水解,雌激素依赖型基因表达等通路.PPI网络共得31个中枢基因,且中枢基因PRKACB参与胰岛素分泌通路;共筛选出3个最有意义的基因...
Serum levels of hsa‐miR‐16‐5p, hsa‐miR‐29a‐3p, hsa‐miR‐150‐5p, hsa‐miR‐155‐5p and hsa‐miR‐223‐3p and subsequent risk of chronic lymphocytic leukemia in the EPIC studychronic lymphocytic leukemiacirculating miRNAserumprospective study...
Helicobacter pylori controls NLRP3 expression by regulating hsa-miR-223-3p and IL-10 in cultured and primary human immune cells.doi:10.1177/1753425917738043Suneesh Kumar PachathundikandiSteffen BackertInnate ImmunPachathundikandi SK, Backert S. Helicobacter pylori controls NLRP3 expression by regulating...
Using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC), the predictive values of five promising human miRNAs ( hsa‐miR‐16‐5p , hsa‐miR‐29a‐3p , hsa‐miR‐150‐5p , hsa‐miR‐155‐5p and hsa‐miR‐223‐3p ), identified in ...