migration, and autophagy”的文章,该研究表明Hsa_circ_0001402作为miR-183-5p海绵,通过提高FKBPL水平抑制VSMC的增殖和迁移,同时提高BECN1水平激活VSMC自噬,从而缓解新生内膜增生。hsa_circ_0001402/miR-183-5p/FKBPL轴和hsa_circ_0001402/miR-1835p/BECN1轴可能为新生内
Results Degenerative discs showed elevated expression of hsa-miR-183-3p, which may be upregulated by TNF-α via NF-κB signaling pathway and target ataxia-telangiectasia mutated protein regulation. Conclusion Degeneration of the intervertebral disc can be accelerated by TNF-α. Additionally, H...
LNC-HC rescued the expression of 5 tumor suppressors, including AKAP12, DYRK2, FOXN3, FOXO1 and LATS2, that were verified as target genes of hsa-miR-183-5p. Overall, human LNC-HC was identified as a novel tumor suppressor that could inhibit HCC cell proliferation in vitro and suppress ...
近日,来自河北医科大学心血管医学中心的研究者们在J Adv Res杂志上发表了题为“Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy”的文章,该研究表明Hsa_circ_0001402作为miR-183-5p海绵,...
doi:10.1016/j.jare.2025.03.048Elsevier B.V.Journal of Advanced Research