hsa-miR-1343-3p and hsa-miR-6783-3p levels were significantly high in individuals with CYP2C19 rs4244285 mutant genotype and these miRNAs down-regulated the protein expression of CYP2C19.#We demonstrated the role of coding mirSNP (rs4244285) in the regulation of the CYP2C19 gene through miRNAs ...
In conclusion, hsa_circ_0088036 functions as an oncogene by targeting the miR-1343-3p/Bcl-3 axis via TGF beta/Smad3/EMT signaling pathway.doi:10.1002/mc.23547Ge, PengChen, XinLiu, JuanJing, RuijunZhang, XingxingLi, HanjieJohn Wiley & Sons, Ltd.Molecular Carcinogenesis...
Coding SNPs in hsa-miR-1343-3p and hsa-miR-6783-3p target sites of CYP2C19 modulates clopidogrel response in individuals with cardiovascular diseasesClopidogrelmiRNA pharmacogenomicsPharmacoepigeneticsmirSNPsmiRNAsDrug responseAims: To investigate the impact of microRNA target SNPs (mirSNPs) and their ...
Functionally, hsa_circ_0088036 silencing inhibited proliferative, invasive, and migrative potential of NSCLC cells as well as epithelial-mesenchymal transition (EMT)-related proteins by sponging miR-1343-3p to inhibit Bcl-3. Furthermore, mechanistic experiments demonstrated that hsa_circ_0088036 promoted...