目的:探讨hsa-miR-103a-3p影响食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)细胞对奥沙利铂(oxaliplatin,OXA)耐药的机制.方法:采用RT-qPCR验证测序结果中hsa-miR-103a-3p在不同ESCC细胞系中的表达;转染hsa-miR-103a-3p mimics或inhibitor,验证hsa-miR-103a-3p是否可以逆转ESCC细胞系的耐药表型.应用...
摘要: 目的 探讨血清hsa-miR-22-3p、hsa-miR-103a-3p水平检测在诊断子宫腺肌病中的应用.方法 将2017年2月至2018年2月该院收治的子宫腺肌病患者216例纳入观察组,同时招募同时间于该院体检的60名健康者作对照组.采用实时荧光定量PCR(qRT-PCR)检测所有受试者血清中hsa-miR-22-3... 查看全部>> ...
miR-103a-3pCCNE1Non-small cell lung cancerRecently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumor progression. However, the roles of hsa_circ_0062389 in non-small cell lung cancer (NSCLC) development remain unclear. In the present study, hsa_circ_0062389...
hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression.doi:10.1016/j.cancergen.2019.12.004Yahui SheYuanyuan HanGuangting ZhouFangyan JiaTan YangZuojun ShenCancer Genet
Conclusion CircBAGE2 contributes to PCa progression by upregulating CCND1 and PDCD10 expression through its role as a 'sponge' of miR-103a-3p. CircBAGE2 may be a potential therapeutic target for PCa.doi:10.1007/s10330-020-0454-4Chunlei ZhangDan LiuQinqin TianQi YangXiaoyuan ZiYinghao Sun《...