利用miRcode网站和RNAhybrid网站预测p63和hsa-let-7b-5p结合,利用实时荧光定量PCR检测hsa-let-7b-5p及p63表达情况.结果 hsalet-7b-5p的高表达对HaCaT细胞的增殖,迁移和侵袭均有抑制作用,hsa-let-7b-5p表达的抑制则促进了HaCaT细胞的增殖,迁移和侵袭.通过网站预测发现hsa-let-7b-5p可与对皮肤表皮细胞有重要作用的...
摘要: 目的 研究在人表皮细胞中hsa-let-7b-5p的作用和其对 ΔNp63表达变化的影响,探讨hsa-let-7b-5p如何影响人表皮细胞的生物功能.方法 人角质形成细胞株(HaCaT)分别转染hsa-let-7b-5p mimic NC、hsa-let-7b-5p mimic、hsa-let-7b-5p inhibi... 查看全部>> ...
Hyperglycemia-related FAS gene and hsa-let-7b-5p as markers of poor outcomes for ischaemic strokehyperglycemiaischaemic strokemicroRNAmodified Rankin Scalemessenger RNABackground and purpose Hyperglycemia in acute stroke leads to poor neurological outcomes. The role of microRNA (miRNA) in hyperglycemia-...
In conclusion, the present study demonstrated that serum-derived exosomal hsa-let-7b-5p is upregulated in patients with CHD and hyperglycemia, and may serve as a noninvasive biomarker for the severity of coronary stenosis.doi:10.3892/mmr.2023.13090Han, Shufang...
Glioma, MicroRNA, hsa-let-7b-5p, Biomarker, Bioinformatics analysisBackgroundGlioma accounts for a large proportion of cancer, and an effective treatment for this disease is still lacking because of the absence of specific driver molecules. Current challenges in the treatment of glioma are the ...