Rap1等信号通路.hsa_circ_0076931可以下调靶基因hsa-miR-26a-5p,hsa-miR-181a-5p和hsa-miR-34a-5p表达,上调双特异性磷酸酶5(DUSP5),血小板衍生生长因子受体(PDGFRB)和钙通道β3亚基(CACNB3)的表达,并抑制磷酸化ERK(p-ERK)蛋白的表达.结论:hsa_circ_0076931可能通过吸附hsa-miR-181a-5p结合上调DUSP5的表达...
hsa-miR-181a 可与固有免疫基因 TLR4 相互作用,并同时作用于与脑卒中相关的其它靶基因,通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导等 KEGG 信号通路发挥作用。固有免疫信号分子 hsa-miR-181a 可通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导等信号通路调节脑卒中,为进一步...
(gene ontology,GO)和信号通路分析.hsa-miR-181a可与固有免疫基因TLR4相互作用,并同时作用于与脑卒中相关的其它靶基因,通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导等KEGG信号通路发挥作用.固有免疫信号分子hsa-miR-181a可通过调节细胞途径,影响代谢过程等生物学途径,神经营养因子信号转导...
Hsa_circ_0001658 acted as a sponge of hsa-miR-181c-5p. Hsa-miR-181c-5p down-regulated the expression of FAS, promoted the proliferation and inhibited the apoptosis of hNPCs. Hsa_circ_0001658 functioned in hNPCs through targeting hsa-miR-181c-5p/FAS. Conclusion: Circular RNA hsa_circ_...
Weaker trends were also observed towards down- regulation in PD with respect to CTR for hsa-miR-150-5p, and, in dnPDs with respect to CTR and to CENT for hsa-miR-144-3p. In a conservative perspective all four miRNAs were retained for the following network-based in silico analysis. In ...
Exosomal miR-590-5p in serum as a biomarker for the diagnosis and prognosis of gastric cancer[J]. Front Mol Biosci, 2021,8:636566. DOI: 10.3389/fmolb.2021.636566 . 返回引文位置Google Scholar 百度学术 万方数据 [7] 游慧慧,丁燕,周艳兰. 胃癌患者血清外泌体中miRNA-21的表达及其临床意义[J]...
Qi Y, He J, Zhang Y, Wang L, Yu Y, Yao B, Tian Z (2021) Circular RNA hsa_circ_0001666 sponges miR-330-5p, miR-193a-5p, and miR-326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4. Oncol Rep 45(4):1–12. https://doi.org/10.3892/or.2021.8001 ...
目的探讨hsa-miR-26b表达沉默对脂肪细胞蛋白分泌的影响.方法将hsa-miR- 26b表达沉默组及对照组慢病毒感染人脂肪前体细胞,在诱导分化过程中收集不同时间点的细胞培养基上清液,采用ELISA法检测IL-6和瘦素 (leptin)的分泌量.结果在细胞分化过程中,hsa-miR-26b表达沉默组IL-6与leptin表达量均较对照组降低(P〈0.01或P...
NSCLC cells were trypsinized and seeded into 96-well plates at a concentration of 2 × 104 cells/ml. After culture at 37 °C for 24 h, NSCLC cells were transfected with the corresponding oligonucleotides (Circ OE, si-Circ, and anti-miR-182-5p), followed by treatment with var...
Moreover, circSETD3 inhibits the growth of HCC partly through the circSETD3/miR-421/MAPK14 pathway. Background Heaptocellular carcinoma (HCC) is the most common primary hepatic malignancy and is a serious health problem worldwide [1, 2]. It is the fifth most common cancer and the third...