本发明涉及一种筛查急性高原反应易感者的microRNA标志物,所述microRNA为hsamiR15b5p作为急性高原反应易感者分子标志物的应用,可以在制备筛查急性高原反应易感者的试剂或试剂盒中应用.更提供一种通过实时荧光定量PCR方法对受测人平原血浆中hsamiR15b5p分子进行检测的试剂盒,并通过其表达水平的高低来预测急性高原反应...
Transfection of miR-15a-5p mimics in cell lines, with high miR-15a-5p expression (Additional file1: Fig. S1D–F) and miR-15a-5p overexpression promoted cell proliferation (Fig.3A–B), migration (Fig.3C–F, H, J), and invasion (Fig.3G, I). Flow cytometry demonstrated that as compar...
circ_0004276和circ_0003060等)、10个共表达miRNA(如miR-183-5p,miR-29b和hsa-miR-15b-3p等)以及241个共表达mRNA(如骨糖蛋白基因、SMARCC1和LRP6等),并成功构建了骨质疏松相关circRNA-miRNA-mRNA网络;②GO分析结果揭示了78个生物过程,其主要包括成骨细胞增殖、凋亡和迁移等功能;③KEGG分析FoxO信号通路和PI3K-AKT...
本发明涉及一种筛查急性高原反应易感者的microRNA标志物,所述microRNA为hsamiR15b5p作为急性高原反应易感者分子标志物的应用,可以在制备筛查急性高原反应易感者的试剂或试剂盒中应用.更提供一种通过实时荧光定量PCR方法对受测人平原血浆中hsamiR15b5p分子进行检测的试剂盒,并通过其表达水平的高低来预测急性高原反应...
Overall, the data indicate the antithetical regulation of Ihh versus has-miR-195-5p and has-miR-15b-5p during the differentiation process. These results support the hypothesis that these mi-RNAs could target the Ihh in the pathway of osteoblast differentiation derived from human ASCs....
本发明具体公开了一种hsa‑miRNA‑155‑5p(简称miR‑155)在制备抑制肠道病毒71型(简称EV71)药物中的用途。本发明利用分子生物学技术发现EV71感染细胞后,能使胞内的miR‑155表达升高。miR‑155可通过靶向磷脂酰肌醇网格蛋白装配蛋白PICALM,进而抑制EV71的复制。本发明的上述应用为诊断和治疗EV71引发的疾病如...
本发明涉及hsamiR15b5p作为筛查急性高原反应易感者唾液中的microRNA标志物的应用,所述microRNA在制备筛查急性高原反应易感者的试剂或试剂盒中应用,唾液标本中hsamiR15b5p表达与对照中的表达相比被下调.更提供一种通过实时荧光定量PCR方法对受测人平原唾液中hsamiR15b5p分子进行检测的试剂盒,并通过其表达水平的高低来...
本发明涉及hsamiR15b5p作为筛查急性高原反应易感者唾液中的microRNA标志物的应用,所述microRNA在制备筛查急性高原反应易感者的试剂或试剂盒中应用,唾液标本中hsamiR15b5p表达与对照中的表达相比被下调.更提供一种通过实时荧光定量PCR方法对受测人平原唾液中hsamiR15b5p分子进行检测的试剂盒,并通过其表达水平的高低来...
Use of at least one micro (mi)RNA comprising hsa-miR-126, hsa-miR-15b, hsa-miR-16, hsa-miR-17, hsa-miR-20a, hsa-let7a, hsa-let 7f, hsa-let 7d, hsa-miR-374, hsa-miR-409, hsa-miR-134, hsa-miR-339, hsa-miR-127, hsa-miR-151, hsa-miR-26b, hsa-miR-34b, hsa-miR-155,...
The expression levels of hsa-miR-15b-5p, hsa-miR-99b-5p, and hsa-miR-181a-5p were quantified by TaqMan miRNA Assays. Putative targets were analyzed by qRT-PCR. Results: Significant downregulation of all three miRNAs investigated was observed in tumorous samples compared to adjacent normal ...