miR-135-5pCircular RNAshave participated in oncology progress. Nevertheless, the potential mechanisms are not completely understood. We intended to inspect the functions of hsa_circ_0088088 on breast malignancy, together with the possible mechanism(s). hsa_circ_0088088 expression in breast malignancy ...
The cell proliferation experiments found that si-hsa_circ_0000847 + miR-135a-5p mimics can significantly inhibit the proliferation of liver cancer cells in the HepG2 + pHBV1.3 cell group (Figure 6(a)). Similarly, the HepG2.2.15 cell group has similar results, and the ability to...
Liu et al. found that circRNA AFF4 activated the SMAD1/5 signaling pathway by binding to miR-135a-5p and played a role in the bone differentiation of BMSCs [21]. Han et al. revealed that hsa_circ_0076690 was significantly correlated with bone mineral density (BMD) in patients with OP...
通过双荧光素酶报告基因实验发现hsa-circ-000094与hsa-miR-370-5p的结合效率最高。Li等[19]认为hsa-miR-370-5p可以激活P21基因的表达;而Ahn等[20]研究发现,2型糖尿病患者胰岛80%缺乏p21(Cdc42/Rac)激酶PAK1,PAK1涉及β细胞功能...
目的:探讨hsa-miR-199a-5p在缺血性脑卒中(IS)患者血清中的表达和意义.方法:收集118例IS患者及125例健康人群的血清标本.通过实时荧光定量PCR(q PCR)检测血清hsa-miR-199a-5p的表达,用ROC曲线分析hsa-miR-199a-5p表达应用于诊断IS的价值,并对hsa-miR-199a-5p表达与研究人群的临床特征进行相关性分析.结果:hsa...
目的:观察miR-218对肺癌细胞生物学行为的影响并探讨其可能的作用机制.方法:收集62例肺癌患者癌组织及癌旁正常组织,qRT-PCR和免疫组化方法检测miRNA-218,LASP1和TGF-β... 张苑,韩鹏凯,王静,... - 《中国免疫学杂志》 被引量: 0发表: 2021年 miR-6886-5p通过调控LASP1表达抑制胃癌细胞的增殖和迁移 目的观察...
Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression. Oncogene. 2019;38:6017–34. Article CAS PubMed Google Scholar Cheng Z, Yu C, Cui S, Wang H, Jin H, Wang C, et al. circTP63 functions as a ceRNA to promote lung ...
MCE 国际站:hsa-miR-134-5p mimic 产品活性:hsa-miR-134-5p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 研究领域:Epigenetics 作用靶点:MicroRNA 相关产品:hsa-miR-4728-3p agomir | hsa-miR-126-3p agomir | rno-miR-6323 antagomir | ...
reported that hsa_circ_0106800, which is derived from PGAP3, suppressed cervical cancer tumorigenesis by regulating the miR-769-5p/p53 axis [27]. Interestingly, He et al. unveiled that hsa_circ_0106800 generated from PGAP3 promotes the proliferation and invasion of triple-negative breast cancer ...
Highest significant dysregulation (Padj < 0.00001) was detected for hsa-miR-21-5p, -215-5p and -378a in both colon and rectal cancer. Among the group of miRNAs with Padj < 0.05 and more than 2-fold expression differences, hsa-miR-375 was detected in rectal cancer ...