Importantly, hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. Taken together, hsa_circ_001783 may serve as a novel prognostic and therapeutic target for breast cancer.doi:10.1038/s41419-018-1287-1Liu, Zihao...
showed thathsa_ circ_ 0021727 was upregulated in ESCC cells. We then confirmed the cyclic character of hsa_circ_0021727. First, we digested total RNA using RNase R. The results showed that hsa_circ_0021727 had stronger RNase R resistance than linearCD44(Fig.1E). Then, we designed random ...
We found hsa_circ_001783 increased significantly by 1.5-2 folds while 7 miRNAs, predicted targets of hsa_circ_001783, were remarkably reduced (fold change>1.5) in mRNA expression levels in BT549, MDA-MB-468 and MDA-MB-231 as compared with MCF-7 breast cancer cell lines. Among all the ...