Additionally, our findings suggest that these radiomic features are more directly related to HRD than to the triple-negative phenotype, which is commonly linked to HRD.Conclusions:We found that four radiomic features from MRI have significant predictive value for identifying HRD in breast cancer. ...
5. Yuan P, Ma N, Xu B. Poly (adenosine diphosphate-ribose) polymerase inhibitors in the treatment of triple-negative breast cancer with homologous repair deficiency. Med Res Rev. 2024 Jun 24. 6. Tung, Nadine M et al...
6. Homologous Recombination Deficiency in Breast Cancer: implications for risk, cancer development and therapy
文献二:乳腺癌 标题:Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities 期刊:Nature Communications IF:14.919 研究思路:这项研究中作者全面分析了原发性乳腺癌和乳腺癌脑转移肿瘤样本中的基因组、转录组和临床特征,并揭示了乳腺癌脑转移的特异...
3. Popova, T., Manie, E., Rieunier, G., Caux-Moncoutier, V., Tirapo, C., Dubois, T., … Stern, M.-H. (2012). Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation. Cancer Research, 72(21), 5454–5462. doi:10.1...
4. Investor science conference call:European Society for Medical Oncology (ESMO) Congress 2019 5. 上皮性卵巢癌PARP抑制剂相关生物标志物检测的中国专家共识 6. Homologous Recombination Deficiency in Breast Cancer: implications for risk, cancer development and therapy...
1. Garutti M, Pelizzari G, Bartoletti M, Malfatti MC, Gerratana L, Tell G, et al. Platinum salts in patients with breast cancer: a focus on predictive factors. Int J Mol Sci. 2019;20(14):3390. 2. Koboldt, D. C. et al. Comprehensive molecular portraits of human breasttumours. Natu...
KEY OBJECTIVE: Carboplatin was added to the standard neoadjuvant anthracycline-taxane regimens to further improve the pathologic complete response (pCR) rate of patients with triple-negative breast cancer, and platinum-based neoadjuvant chemotherapy was associated with a significant increase in event-free ...
■研究题目:The status of homologous recombination deficiency is a potential biomarker for platinum-based chemotherapy in triple-negative breast cancer ■海报编号:P1-08-12 ■公布时间:12月8日7:00 am～8:30 am CT 研究背景 三阴性乳腺癌(TNBC)是一种极易复发和转移的亚型,由于缺乏治疗靶点,治疗方案仍以...
[5].LYNPARZA? (olaparib) Approved by US FDA in Germline BRCA-Mutated Metastatic Breast Cancer 莲和医疗健康集团有限公司 Life Healthcare Group Limited 莲和医疗健康集团有限公司(股份代码:HKEX 00928)是一家在香港上市、专注于肿瘤精准医疗领域的生物技术公司,致力于肿瘤基因检测在临床医学与健康服务中的推广...