Additionally, our findings suggest that these radiomic features are more directly related to HRD than to the triple-negative phenotype, which is commonly linked to HRD.Conclusions:We found that four radiomic features from MRI have significant predictive value for identifying HRD in breast cancer. ...
5. Yuan P, Ma N, Xu B. Poly (adenosine diphosphate-ribose) polymerase inhibitors in the treatment of triple-negative breast cancer with homologous repair deficiency. Med Res Rev. 2024 Jun 24. 6. Tung, Nadine M et al...
1.http://www.cmaamed.com/news/show/id/132 2. Murfuni, I., & Rass, U. (2016). Targeting homologous recombination repair in cancer. DNA Repair in Cancer Therapy, 225–275. doi:10.1016/b978-0-12-803582-5.00008 3. Popova, T., Manie, E., Rieunier, G., Caux-Moncoutier, V., Ti...
[8] Sztupinszki, Z. et al. Migrating the SNP array-based homologous recombination deficiency measures to next generation sequencing data of breast cancer. NPJ Breast Cancer 4, 16, doi:10.1038/s41523-018-0066-6 (2018). [9] Timms, K. M. et...
标题:Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities 期刊:Nature Communications IF:14.919 研究思路:这项研究中作者全面分析了原发性乳腺癌和乳腺癌脑转移肿瘤样本中的基因组、转录组和临床特征,并揭示了乳腺癌脑转移的特异性转录组特征,鉴...
[3]Telli M L , Timms K M , Reid J E ,et al.Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer[J].Clinical Cancer Research An Official Journal of the American Association for Cancer Resear...
[9] Timms, K. M. et al. Association of BRCA1/2 defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes. Breast Cancer Res 16, 475, doi:10.1186/s13058-014-0475-x (2014). [10] https://www.jkangpathology.com/slide/scarhrd/slides/scarhrd#5 ...
■ 研究题目:Homologous recombination deficiency predicts the response to platinum-based neoadjuvant chemotherapy in patients with early-stage triple-negative breast cancer: A meta-analysis ■ 海报编号:P1-08-32 ■ 公布时间:12月8日7:00 am～8:30 am CT ...
KEY OBJECTIVE: Carboplatin was added to the standard neoadjuvant anthracycline-taxane regimens to further improve the pathologic complete response (pCR) rate of patients with triple-negative breast cancer, and platinum-based neoadjuvant chemotherapy was associated with a significant increase in event-free ...
[3] LIPS E H,LADDACH N,SAVOLA S P,et al. Quantitative copy number analysis by Multiplex Ligation⁃dependent Probe Amplification(MLPA)of BRCA1⁃associated breast cancer regions identifies BRCAness[J].Breast Cancer Res,2011,13(5):R107....