Isolated substances were identified by HR-ESI-MS and IC50s determined and compared with 5-fluorouracil (5-FU) reference standard.Results: The HR-ESI-MS spectrum under negative ion mode revealed the parent molecular ion peaks of the semipreparative fractions (FR15-6 and FR15-7), whose IC50s...
In the MS/MS spectrum, the fragment ions at m/z 186.0786 (C11H10ON2) and m/z 160.0757 (C10H10ON) were observed after the loss of a methyl group and a C2H3N residue, respectively. Therefore, Peak 33 was identified as 1-methyl-2,9-dihydro-1H-pyrido [3–β] indol-6-ol (Figure ...
(D) low energy spectrum of the peak at Tr = 3.19 min in panel B, showing the [M-H]+ ion of HFB1 (observed accurate mass at m/z = 406.3527, mass error: 0.0 mDa or 0.1 ppm); (E) high energy spectrum of the same peak, showing fragment ions of HFB1 at m/z = 334.3095 and ...
Sapphire from Nu is a next generation Multi-Collector ICP-MS. The collision cell capable instrument builds on the field proven Nu Instruments Multi-Collector ICP-MS platform (with over 170 installed instruments worldwide) to add unrivalled capabilities. The Sapphire features high and low energy swit...
Withdrawn as duplicate: Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review This article has been withdrawn due to a publisher error that caused it to be duplicated. The definitive version of this article is published under https://doi.org/10....
HR ESI positive mode MS spectrum of complex 5.Takatoshi, KarasawaMartha, SibrianVazquezRobert, M. StronginPeter, S. Steyger
euchroma was achieved under the guidance of the spectrum-effect relationship obtained above. Finally, the isolated compounds were elucidated by extensive spectroscopic methods and their bioactivities were validated by in vitro assay and molecular docking. Results 16 potential active ingredients in A. eu...
The calcium isotope spectrum obtained from an ICP-MS using conventional spray chamber, operated in low resolution mode LR 300, is subject to numerous polyatomic, isobaric and doubly charged interferences. The most severe polyatomic interfences can be resolved at resolutions greater than 3500, whereas...
Antibacterial spectrum showed significant minimal inhibitory concentration as 0.5 μg/ml of PVI401 and 2 μg/ml of PVI402 against MRSA. The whole organism zebrafish safety evaluation exhibited the compound PVI402 is safe upto 1 mg/ml 40 μg/ml of PVI401 exhibited thrombosis in cardiac chamber...
The DIA method relied on a post-targeted reverse database search and the DDA method on a spectrum library search, each comprising the same selection of 200 drugs of abuse. The performance between the methods was compared in terms of the limit of identification (LOI) and specificity. The ...