Between 13 and 18 HPV strains have been characterized as conferring a high oncogenic risk, with 12 of these strains belonging to the HPV species 7 (HPV-18, -39, -45, -59, -68) and species 9 (HPV-16, -31, -33, -35, -52, -58, -67). While strains belonging to the same ...
While greater than 90% efficacy has been demonstrated at the completion of large phase III trials in young women, vaccines developers are now addressing broader issues such as efficacy in boys, longevity of the protection and inducing cross reactive antibody for oncogenic non-vaccine HPV strains. ...
Genetic profiling of Campylobacter jejuni strains from humans infected in Sweden or in Thailand, and from healthy Swedish chickens, studied by pulsed- field gel electrophoresis (PFGE)[J]. Scand J Infect Dis, 2005, 37(8): 579-584. [ 11 ] RAGIMBEAU C, SCHNEIDER F, LOSCH S, et al. ...
Cervicovaginal microbial structure has been associated with HPV infection [27], high-risk HPV infection type [26], and cervical abnormalities [29,30]. For the female reproductive tract, health is usually associated with low microbial diversity and the predominance of only one or a few lactic aci...
Recently, an accurate HPV genotyping algorithm was developed using metagenomic DNA data, which uses a strategy of masking simple repeats and homology sequences10; however, this methodology does not take into account expression of HPV related proteins, including the capacity of some viral strains to ...
Variations of human papillomavirus type 58 E6, E7, L1 genes and long control region in strains from women with cervical lesions in Liaoning province, China. Infect Genet Evol. 2012;12:1466–72. https://doi.org/10.1016/j.meegid.2012.05.004. Article CAS PubMed Google Scholar Le Cleach L...
NGS analysis is probably the most sensitive methodology for HPV analysis because of the high sequence homology of HPV types, large diversity of the virus family, and multiple HPV strains infecting a single individual. However, we could not disregard the possibility of false positives even for NGS...
Among HR-HPV strains, the HR-HPV16 and 18 are responsible for the most cases of cervical cancer, followed by types 31, 33, 45, 52 and 58 [3]. Cervical cancer is the third most common cancer among women worldwide, with an estimated 569,847 new cases, and 311,365 deaths in 2018 [...
Gardasil® and Cervarix® have not been comprehensively mapped, although emerging data point to higher levels of neutralizing antibodies6,15, T cell responses, B cell responses, and cytokine responses following Cervarix® vaccination compared to Gardasil® against common HPV16/18 strains6,14,16...
HPV infection with certain viral strains is linked to virtually every case of cervical cancer, 90% of anal cancers, and 40% of other genital cancers [2]. Additionally, while the burden of high-risk oral HPV infection in the population is low (around 4%) [3], oropharyngeal squamous cell ...