Although more than half of countries (55%) globally have introduced the HPV vaccine, due to different population sizes, 70% of girls globally still live in countries that have not yet introduced. This is explained by the fact that 7 of the 10 top most populous countries have not yet ...
well over 200 HPV types have been identified and fully sequenced10. The viral life cycle and how it causes disease have been most thoroughly studied in cervical dysplasia and carcinomas, where initial infections are established in the basal layer of the epithelia. As epithelial cells differentiate...
The observed effects could in part be explained by the E6-induced decrease in the cellular antioxidant activity, as the expression of this E6 isoform led to a decreased expression of superoxide dismutase isoform 2 and glutathione peroxidase [95]. Due to their state of chronic oxidative stress, ...
similar in oral and anal infections (mean values 24.3% and 20.9%, p-value = 0.6417). Among the 68 patients with HR, LR, or undetermined genotypes at the baseline in their anus who provided two consecutive anal samples, 75% (51/68) had persistent HPV six months after enrolment. Persistenc...
Expression of one of the isoforms of HPV16 oncoprotein E6 increases the levels of ROS in both HPV-positive and HPV-negative cells, resulting in DNA damage, reliably detected by several assays. The observed effects could in part be explained by the E6-induced decrease in the cellular antioxidant...
(which explained 40% of the variance in cytokine expression), both supporting the regression analyses and emphasizing the general similarity in cytokine profile observed among women with a history of HPV infections relative to women who remained HPV negative. The model also identified a clustering of...
This negative result may be explained by the lack of adequate processing and MHC-I-mediated presentation of the HPV16 E7(11-19) peptide. The identification of HLA-restricted HPV16 E7 T-cell epitopes may necessitate a more comprehensive epitope mapping and subsequent testing. The IFN-γ ELISPOT-...
Each participant was needed to give written informed consent after the researcher explained the study’s nature, purpose, and methodology. Each participant signed the willingness confirmation after getting their approval. All study participants have been informed that the data will be treated as ...
OPSCC makes up a substantial proportion of all OPSCC cases and this number is rising, mainly in the Western world. This is most likely due to changes in sexual behaviour [62,63]. The significant gender differences in the prevalence of HPV positive tumours could be explained by the ...
The Variable Importance in Projection (VIP) score of each selected feature, which explains the feature’s loading weights and the variance of the response (i.e. the vaccine group) explained by the feature, was calculated. For validation of the classification model, alternate models were built ...