The high-risk genotypes include HPV 16 and 18, which are responsible for a variety of human cancers. The most common malignancies that are associated with HPV infection are cervical cancer, oropharyngeal cancer and anal cancer. Screening for HPV precursor lesions in women has led to a drastic ...
参考文献: Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020 Nov 15;17(4):864-878. doi: 10.20892/j.issn.2095-3941.2020.0370. Epub 2020 Dec 15. PMID: 33299640; PMCID: PMC7721094. Dunne EF, Park IU. HPV and HPV-associated diseases....
1.SCG Presented Preclinical Data in an Oral Presentation at ASGCT 2024 Highlighting Superior Tumor Inhibition of its Immunoswitch Armored HPV-TCR T Cell Therapy (SCG142) against HPV-associated Cancers-SCG Star Handset (scgcell.com)2.Safety and clinical activity of gene-engineered T-cell therapy ...
The number of cancers associated with the human papillomavirus (HPV) has increased in the United States in recent years, according to a new report from the Centers for Disease Control and Prevention (CDC). HPV-associated malignancies include cervical, vulvar, vaginal, penile, oropharyngeal, anal, ...
HPV-associated cancers: insights into the mechanistic scenario and latest updates. Med Oncol. 2023 Jun 26;40(8):212. doi: 10.1007/s12032-023-02085-8. PMID: 37358816. 编辑于 2023-09-26 16:53・浙江 HPV 癌症 海尔施基因科技 赞同2添加评论 分享喜欢收藏申请转载 ...
[6]Chaturvedi, A.K., Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women.Journal of Adolescent Health, 2010. 46(4): p. S20-S26. [7]Chabeda, A., et al., Therapeutic vaccines for high-risk HPV-associated diseases. Papillomavirus Research, 2018. 5: p. 46...
HPV相关性癌症(HPV-associated cancer)是一种特定细胞类型的癌症,这些癌症在经常发现HPV的部位诊断出,这些部位包括子宫颈、阴道、外阴、阴茎、肛门、直肠和口咽(咽喉的后部,包括舌头和扁桃体的底部)。 HPV引起的癌症(HPV-attributable cancer)顾名思义,是由HPV病毒引起的癌症。HPV导致了几乎所有宫颈癌和许多阴道、外阴...
Additionally, to make the T cells more active, they have been engineered to make them resistant to transforming growth factor beta (TGF-β) which is produced by HPV cancers [141]. A phase I trial in patients with relapsed HPV-associated cancers (HESTIA) is currently recruiting participants to...
2、Rusan M, Li Y Y, Hammerman P S. Genomic Landscape of Human Papillomavirus–Associated Cancers[J]. Clinical Cancer Research, 2015, 21(9): 2009-2019. 3、Parfenov M, Pedamallu C S, Gehlenborg N, et al. Characterization of HPV and host genome interactions in primary head and neck can...
该团队构建了可以递送mRNA的pH响应性基因编辑系统,在HPV18阳性相关宫颈癌中,采用CRISPR基因疗法,特异靶向敲除HPV18病毒的E6和E7基因,并在基因编辑实现抗肿瘤效应的基础上,联合脐血淋巴细胞局部应用,可有效促进肿瘤局部微环境中的T细胞存活及CD...