HPPHypophosphatasia(bone disease) HPPHamiltonian Path Problem(graph theory) HPPHazard Prevention Program(Canada) HPPHypno-Peripheral Processing HPPHeader C++ HPPHp Partner Portal HPPHp Printer HPPHigh Performance Package HPPHead Phones President(band) ...
英国国家卫生与临床优化研究所(NICE)近日发布指南,推荐扩大美国知名罕见病制药商Alexion药物Strensiq(asfotase alfa)在英国国家卫生服务系统(NHS)的应用,用于超罕见小儿发病低磷酸酯酶症(HPP)患者的治疗。从前。Strensiq仅被批准用于患有该病最...
Hypophosphatasia (HPP) is a multisystem disease with deleterious effects that can appear at different ages and progress over time. In adults, the symptoms of HPP are often misdiagnosed and confused with other, more common, bone or rheumatologic diseases, leading to delayed diagnosis and inappropriate...
The baseline disease burden in patients with adult-onset HPP is presented in Fig. 4. A history of pain (64.5%), dental (42.6%), skeletal (37.6%), constitutional/ metabolic (23.4%), and renal (21.3%) manifestations were most common among this population. Chronic bone pain (52.5%) and...
Although HPP is a physical disease, several studies have found that mental health can also be affected. [1, 23] Various other treatments have been attempted, including zinc, magnesium, cortisone, and plasma. The results have not been encouraging with these older therapies. Donor bone fragments...
BONE densitySYMPTOMSHypophosphatasia (HPP) is an inborn error of metabolism caused by reduced or absent activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, resulting from pathogenic variants in the ALPL gene. Clinical presentation of HPP is highly variable, including lethal and...
在欧盟,Strensiq于2015年8月底获批,作为一种长期的骨靶向酶替代疗法,用于小儿发病低磷酸酯酶症患者的治疗。在美国,Strensiq于2015年10月底获批,用于围产儿、婴儿及青少年低磷酸酯酶症患者的治疗。 原文出处:NICE agrees approval deal for ultra-rare juvenile bone disease...
infectious pulmonary diseases, those with IPF or healthy volunteers.HPP-CFCs were frequently found in the peripheral blood of RA patients with ILD compared with those without ILD, suggesting the mobilization of HPP-CFCs from the bone marrow into the peripheral blood in association with ILD in RA....
Hypophosphatasia (HPP) is an inborn disease that causes a rare form of osteomalacia, a mineralization disorder affecting mineralized tissues. Identification of patients at high risk for fractures or other skeletal manifestations (such as insufficiency fractures or excessive bone marrow edema) by bone ...